Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

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Abstract

Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing. Epigenetic dynamics and immunometabolic reprogramming link to the alterations of cellular response to intrinsic and extrinsic stimuli, representing current hotspots as they not only (re-)shape the individual cell identity, but also involve in cell fate decision. This review focuses on the present findings and emerging concepts in epigenetic, inflammatory, and metabolic regulations and the consequences of the ageing process. Potential therapeutic interventions targeting cell senescence and regulatory mechanisms, using state-of-the-art techniques are also discussed.

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Author and article information

Contributors

Hu Wang: wanghu19860315@163.com

Zhenyu Ju: zhenyuju@163.com

Journal

Journal ID (nlm-ta): Signal Transduct Target Ther

Journal ID (iso-abbrev): Signal Transduct Target Ther

Title: Signal Transduction and Targeted Therapy

Publisher: Nature Publishing Group UK (London )

ISSN (Print): 2095-9907

ISSN (Electronic): 2059-3635

Publication date (Electronic): 28 June 2021

Publication date PMC-release: 28 June 2021

Publication date Collection: 2021

Volume: 6

Electronic Location Identifier: 245

Affiliations

[1 ]GRID grid.410595.c, ISNI 0000 0001 2230 9154, Key Laboratory of Ageing and Cancer Biology of Zhejiang Province, Institute of Ageing Research, , Hangzhou Normal University School of Medicine, ; Hangzhou, China

[2 ]GRID grid.258164.c, ISNI 0000 0004 1790 3548, Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Ageing and Regenerative Medicine, , Jinan University, ; Guangzhou, China

[3 ]GRID grid.239573.9, ISNI 0000 0000 9025 8099, Division of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, ; Cincinnati, OH USA

[4 ]GRID grid.40263.33, ISNI 0000 0004 1936 9094, Department of Molecular Biology, Cell Biology and Biochemistry, , Brown University, ; Providence, RI USA

Article

Publisher ID: 646

DOI: 10.1038/s41392-021-00646-9

PMC ID: 8236488

PubMed ID: 34176928

SO-VID: 808ea1b3-c0f5-458b-ac7d-d59e0ffbdf89

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 20 November 2020

Date revision received : 9 May 2021

Date accepted : 13 May 2021

Funding

Funded by: FundRef https://doi.org/10.13039/501100001809, National Natural Science Foundation of China (National Science Foundation of China);

Award ID: 81525010

Award ID: 82030039

Award ID: 91749203

Award ID: 82071572

Award ID: 81901403

Award ID: 81770155

Award ID: 91749117

Award ID: 82022026

Award Recipient : Xudong Zhu Zhiyang Chen Hu Wang Zhenyu Ju

Funded by: National Key Research and Development Program of China(2016YFA0100602, 2017YFA0103302, 2018YFA0109300); Innovative Team Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (2018GZR110103002) and Program for Guangdong Introducing Innovative and Enterpreneurial Teams (2017ZT07S347).

Funded by: Opening Project of Key Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province (2C32003)

Funded by: Science Foundation for Distinguished Young Scholars of Guangdong Province (2019B151502008)