Transition metal-catalyzed Cvinyl–Cvinyl bond formation via double Cvinyl–H bond activation

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Abstract

Transition metal-catalyzed oxidative dehydrogenative coupling reactions of Caryl-H bonds with Cvinyl-H bonds to generate a Caryl-Cvinyl bonds have been well developed in recent decades. However, only a few studies have focused on the direct Cvinyl-Cvinyl bond formation via double Cvinyl-H bond activation. Recent developments in this active area have been highlighted in this tutorial review.

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Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.

Lutz Ackermann (2011)

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Towards mild metal-catalyzed C-H bond activation.

Joanna Wencel-Delord, Thomas Dröge, Fan Liu … (2011)

Functionalizing traditionally inert carbon-hydrogen bonds represents a powerful transformation in organic synthesis, providing new entries to valuable structural motifs and improving the overall synthetic efficiency. C-H bond activation, however, often necessitates harsh reaction conditions that result in functional group incompatibilities and limited substrate scope. An understanding of the reaction mechanism and rational design of experimental conditions have led to significant improvement in both selectivity and applicability. This critical review summarizes and discusses endeavours towards the development of mild C-H activation methods and wishes to trigger more research towards this goal. In addition, we examine select examples in complex natural product synthesis to demonstrate the synthetic utility of mild C-H functionalization (84 references). This journal is © The Royal Society of Chemistry 2011