Unique nasal septal island in dromedary camels may play a role in pain perception: microscopic studies

Highlights

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  The septal island in dromedaries is a distinctive anatomical structure.

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  It has a curiously rostral location and innervated by the trigeminal nerve.

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  It has an unusual ultrastructure and may be specialized for nociception.

Abstract

The septal organs are islands or patches of sensory epithelium, located in the ventral parts of the nasal septum and innervated by the olfactory nerve. The septal island in dromedaries ( Camelus dromedarius) was unusually located in the rostro-dorsal part of the nasal septum, where the ethmoidal branch of the trigeminal nerve provides innervation to the island mucosa. Therefore, the objectives of this study were to reveal the microscopic and ultrastructure of this island and to explain the probable functions. Twelve septal islands from 12 healthy male camels were used. Unlike the olfactory epithelium, which has a pseudostratified structure, the island neuroepithelium had a true neural lamination. Furthermore, in electron micrographs, the receptor, bipolar, and basal cells were connected with an orderly, organized network of cell–cell communication, which had some spine synapses. This network substituted the absence of supporting cells, maintained the shape of the tissue, and held the cells together. Moreover, the receptor cells were not similar to any of the different types of olfactory sensory neurons. Instead, they possessed the apical domain that might be specialized for the detection of chemical stimuli. Interestingly, a resident population of immune cells, namely mast cells and macrophages, was observed. The probable functions were discussed based on the cellular context and architecture. The nasal septal island in dromedaries may have a role in pain perception. The receptor cells most probably work as nociceptive cells that interact with the resident immune cells to coordinate pain signaling with immune response.