Global interim guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals

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Abstract

In response to the World Health Organization (WHO) statements and international concerns regarding the coronavirus disease 2019 (COVID‐19) outbreak, FIGO has issued comprehensive guidance for the management of pregnant women.

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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, Yeming Wang, Xingwang Li … (2020)

Summary Background A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. Methods All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data. Outcomes were also compared between patients who had been admitted to the intensive care unit (ICU) and those who had not. Findings By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49·0 years (IQR 41·0–58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0–13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα. Interpretation The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. Funding Ministry of Science and Technology, Chinese Academy of Medical Sciences, National Natural Science Foundation of China, and Beijing Municipal Science and Technology Commission.

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Clinical Characteristics of Coronavirus Disease 2019 in China

Wei-jie Guan, Zheng-yi Ni, Yu Hu … (2020)

Abstract Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. Methods We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. Results The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission. Conclusions During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.)

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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

Dawei Wang, Bo Hu, Fangfang Zhu … (2020)

In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.

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Author and article information

Contributors

Moshe Hod: hodroyal@inter.net.il

Journal

Journal ID (nlm-ta): Int J Gynaecol Obstet

Journal ID (iso-abbrev): Int J Gynaecol Obstet

Journal ID (doi): 10.1002/(ISSN)1879-3479

Journal ID (publisher-id): IJGO

Title: International Journal of Gynaecology and Obstetrics

Publisher: John Wiley and Sons Inc. (Hoboken )

ISSN (Print): 0020-7292

ISSN (Electronic): 1879-3479

Publication date (Electronic): 28 April 2020

Publication date (Print): June 2020

Publication date PMC-release: 28 April 2020

Volume: 149

Issue: 3 ( doiID: 10.1002/ijgo.v149.3 )

Pages: 273-286

Affiliations

[ ¹ ] Department of Obstetrics and Gynecology The Chinese University of Hong Kong Hong Kong Hong Kong SAR

[ ² ] Department of Obstetrics and Gynecology Peking University First Hospital Beijing China

[ ³ ] World Diabetes Foundation Bagsværd Denmark

[ ⁴ ] Department of Obstetrics and Gynecology Sunnybrook Health Sciences Center University of Toronto Toronto ON Canada

[ ⁵ ] Jhpiego Ouagadougou Burkina Faso

[ ⁶ ] Divakars Speciality Hospital Bengaluru India

[ ⁷ ] Mater Research Faculty of Medicine University of Queensland Brisbane Australia

[ ⁸ ] African Federation of Obstetricians and Gynecologists Nairobi Kenya

[ ⁹ ] Department of Obstetrics Faculty of Medicine Santa Maria Hospital University of Lisbon Lisbon Portugal

[ ¹⁰ ] Regional Authority of Lombardi IRCCS Foundation Ca’ Granda Ospedale Maggiore Polyclinic Mangiagalli Centre University of Milan Milan Italy

[ ¹¹ ] Center of Perinatal and Reproductive Medicine Department of Obstetrics and Gynecology University of Perugia Perugia Italy

[ ¹² ] IM Sechenov First State University Moscow Russia

[ ¹³ ] Mor Women's Health Care Center Tel Aviv Israel

[ ¹⁴ ] FIGO – Chair, Pregnancy and NCDs Committee Tel Aviv Israel

[ ¹⁵ ] These authors contributed equally

Author notes

[*] [* ] Correspondence

Moshe Hod, Mor Women's Health Care Center, Tel Aviv, Israel.

Email: hodroyal@ 123456inter.net.il

Article

Publisher ID: IJGO13156

DOI: 10.1002/ijgo.13156

PMC ID: 9087575

PubMed ID: 32248521

SO-VID: 73ab7819-b902-4b6d-a6d0-b009c8c08d23

License:

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

History

Date revision received : 03 April 2020

Date received : 25 March 2020

Date accepted : 03 April 2020

Page count

Figures: 4, Tables: 0, Pages: 14, Words: 8178

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source-schema-version-number 2.0

cover-date June 2020

details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:6.1.5 mode:remove_FC converted:10.05.2022

ScienceOpen disciplines: Obstetrics & Gynecology

Keywords: coronavirus disease 2019,covid‐19,management,pneumonia,pregnancy,puerperium,sars‐cov‐2

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ScienceOpen disciplines: Obstetrics & Gynecology

Keywords: coronavirus disease 2019, covid‐19, management, pneumonia, pregnancy, puerperium, sars‐cov‐2

Global interim guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals

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Novel Coronavirus Disease COVID-19

Most cited references 52

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Clinical Characteristics of Coronavirus Disease 2019 in China

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

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