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      Confounding effect of blood volume and body mass index on blood neurofilament light chain levels

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          Abstract

          Blood Neurofilament light chain (NfL) has been suggested as a promising biomarker in several neurological conditions. Since blood NfL is the consequence of leaked NfL from the cerebrospinal fluid, differences in individuals’ Body Mass Index (BMI) or blood volume (BV) might affect its correlation to other biomarkers and disease outcomes. Here, we investigated the correlation between plasma NfL, BMI, and BV in 662 controls and 2,586 multiple sclerosis cases. We found a significant negative correlation between plasma NfL, BMI/BV in both groups. Our results highlight the potential confounding effect of BMI/BV on associations between blood NfL and disease outcomes.

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          Prediction of blood volume in normal human adults.

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            Author and article information

            Contributors
            ali.manouchehrinia@ki.se
            Journal
            Ann Clin Transl Neurol
            Ann Clin Transl Neurol
            10.1002/(ISSN)2328-9503
            ACN3
            Annals of Clinical and Translational Neurology
            John Wiley and Sons Inc. (Hoboken )
            2328-9503
            01 January 2020
            January 2020
            : 7
            : 1 ( doiID: 10.1002/acn3.v7.1 )
            : 139-143
            Affiliations
            [ 1 ] Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
            [ 2 ] Centre for Molecular Medicine Karolinska University Hospital Stockholm Sweden
            [ 3 ] Departments of Medicine, Biomedicine, and Clinical Research Neurologic Clinic and Policlinic University Hospital Basel University of Basel Basel Switzerland
            [ 4 ] Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden
            Author notes
            [*] [* ] Correspondence

            Ali Manouchehrinia, The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neurosciences, Karolinska Institutet, Centre for Molecular Medicine, L8:05, SE‐171 76 Stockholm, Sweden. Tel: +46 738702423: E‐mail: ali.manouchehrinia@ 123456ki.se

            Author information
            https://orcid.org/0000-0003-4857-5762
            Article
            ACN350972
            10.1002/acn3.50972
            6952306
            31893563
            6c5f97cc-f1ba-420a-9377-299bd71d23d9
            © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

            This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

            History
            : 02 December 2019
            : 08 December 2019
            Page count
            Figures: 2, Tables: 0, Pages: 5, Words: 1907
            Funding
            Funded by: Novartis , open-funder-registry 10.13039/100004336;
            Funded by: Biogen , open-funder-registry 10.13039/100005614;
            Funded by: Vetenskapsrådet , open-funder-registry 10.13039/501100004359;
            Funded by: AFA Försäkring , open-funder-registry 10.13039/501100002706;
            Funded by: Genzyme , open-funder-registry 10.13039/100004329;
            Funded by: the Swedish Research Council for Health, Working Live and Welfare
            Funded by: the Swedish Brain Foundation , open-funder-registry 10.13039/501100003792;
            Funded by: Knut , open-funder-registry 10.13039/501100002614;
            Funded by: the Alice Wallenberg Foundation
            Funded by: Margaretha af Ugglas Foundation
            Funded by: EU Horizon 2020 MultipleMS
            Award ID: 733161
            Funded by: Sanofi , open-funder-registry 10.13039/100004339;
            This work was funded by Novartis , open-funder-registry 10.13039/100004336; grant ; Biogen , open-funder-registry 10.13039/100005614; grant ; Vetenskapsrådet , open-funder-registry 10.13039/501100004359; grant ; AFA Försäkring , open-funder-registry 10.13039/501100002706; grant ; Genzyme , open-funder-registry 10.13039/100004329; grant ; the Swedish Research Council for Health, Working Live and Welfare grant ; the Swedish Brain Foundation , open-funder-registry 10.13039/501100003792; grant ; Knut , open-funder-registry 10.13039/501100002614; grant ; the Alice Wallenberg Foundation grant ; Margaretha af Ugglas Foundation grant ; EU Horizon 2020 MultipleMS grant 733161; Sanofi , open-funder-registry 10.13039/100004339; grant .
            Categories
            Brief Communication
            Brief Communications
            Custom metadata
            2.0
            January 2020
            Converter:WILEY_ML3GV2_TO_JATSPMC version:5.7.4 mode:remove_FC converted:09.01.2020

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