Mana Inada: Role: InvestigationRole: Validation
Mika Shindo: Role: Investigation
Kyousuke Kobayashi: Role: Validation
Akira Sato:
ORCID: http://orcid.org/0000-0002-2239-6208
Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: InvestigationRole:
Project administrationRole: SupervisionRole: ValidationRole: Writing – original draft
Yohei Yamamoto: Role: ConceptualizationRole: Formal analysisRole: Validation
Yasuharu Akasaki: Role: ConceptualizationRole: Formal analysisRole: Validation
Koichi Ichimura: Role: ConceptualizationRole: Formal analysisRole: Validation
Sei-ichi Tanuma: Role: ConceptualizationRole: Funding acquisitionRole: Supervision
Ilya Ulasov: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
17
May
2019
Publication date Collection: 2019
Volume: 14
Issue: 5
Electronic Location Identifier: e0216358
Affiliations
[1
]
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of
Science, Noda, Chiba, Japan
[2
]
National Cancer Center Hospital, Chuo-ku, Tokyo, Japan
[3
]
Department of Neurosurgery, Jikei University School of Medicine, Minato-ku, Tokyo,
Japan
[4
]
Division of Brain Tumor Translational Research, National Cancer Center Research Institute,
Chuo-ku, Tokyo, Japan
[5
]
Department of Genomic Medicinal Science, Research Institute for Science and Technology,
Organization for Research Advancement, Tokyo University of Science, Noda, Chiba, Japan
Sechenov First Medical University, RUSSIAN FEDERATION
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-18-35172
DOI: 10.1371/journal.pone.0216358
PMC ID: 6524804
PubMed ID: 31100066
SO-VID: 61c49089-08df-4fc1-8458-2e55299f428e
Copyright © © 2019 Inada et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
This work was supported by a JSPS KAKENHI grant number 26670648 (T.A.) and an Education
Research Fund for Tokyo University of Science (A.S. and S.T.). The funders had no
role in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Subject:
Research Article
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Proliferation
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Motility
Subject:
Cell Migration
Subject:
Cancer Cell Migration
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Cell Migration
Subject:
Cancer Cell Migration
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Immune Receptors
Subject:
Toll-like Receptors
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Immune Receptors
Subject:
Toll-like Receptors
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Immune Receptors
Subject:
Toll-like Receptors
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Signal Transduction
Subject:
Immune Receptors
Subject:
Toll-like Receptors
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Alkaloids
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Drug Research and Development
Subject:
Drug Design
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
Subject:
Cancer Chemotherapy
Subject:
Medicine and Health Sciences
Subject:
Pharmaceutics
Subject:
Drug Therapy
Subject:
Chemotherapy
Subject:
Cancer Chemotherapy
Subject:
Medicine and Health Sciences
Subject:
Clinical Medicine
Subject:
Clinical Oncology
Subject:
Cancer Chemotherapy
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Clinical Oncology
Subject:
Cancer Chemotherapy