Inhibitory Effect of Tannin in Green Tea on the Proliferation of Mesangial Cells

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Abstract

The effect of green tea tannin on the proliferation of mesangial cells was determined in terms of [<sup>3</sup>H]thymidine uptake. When green tea tannin was added to the medium of mesangial cell cultures, it suppressed the proliferation of mesangial cells markedly. In particular, (-)-epigallocatechin 3- O-gallate, the predominant component of the green tea tannin mixture, exerted an inhibitory effect at a relatively low concentration, suggesting a direct corroboration of the renal effects.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1993

Publication date (Print): 1993

Publication date (Electronic): 12 December 2008

Volume: 65

Issue: 4

Pages: 596-600

Affiliations

^aResearch Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama; ^bFirst Department of Internal Medicine, Nara Medical University, Kashiwara, Nara; ^cCentral Research Laboratories, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie, Japan

Article

Publisher ID: 187570 Other ID: Nephron 1993;65:596–600

DOI: 10.1159/000187570

PubMed ID: 8302416

SO-VID: 5bf3e889-d6c6-4bb2-9d1d-5b0c0d1e0407

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 26 February 1993

Page count

Pages: 5

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