Contributors
Dongwei Xu: Role: Data curationRole: Formal analysisRole: InvestigationRole: Writing – review
& editing
Alec Vincent: Role: Data curationRole: Formal analysisRole: InvestigationRole: Writing – review
& editing
Andrés González-Gutiérrez:
ORCID: https://orcid.org/0000-0002-9441-2211
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Benjamin Aleyakpo: Role: Formal analysisRole: InvestigationRole: Methodology
Sharifah Anoar: Role: Investigation
Ashling Giblin:
ORCID: https://orcid.org/0000-0001-8470-7908
Role: Investigation
Magda L. Atilano:
ORCID: https://orcid.org/0000-0002-3819-2023
Role: InvestigationRole: Methodology
Mirjam Adams: Role: Investigation
Dunxin Shen: Role: Formal analysisRole: Investigation
Annora Thoeng:
ORCID: https://orcid.org/0000-0001-9722-7399
Role: Data curationRole: Investigation
Elli Tsintzas: Role: Investigation
Marie Maeland:
ORCID: https://orcid.org/0009-0009-9073-1088
Role: Investigation
Adrian M. Isaacs: Role: ConceptualizationRole: Funding acquisitionRole: Writing – review & editing
Jimena Sierralta:
ORCID: https://orcid.org/0000-0002-0257-146X
Role: Formal analysisRole: Funding acquisitionRole: Writing – review & editing
Teresa Niccoli:
ORCID: https://orcid.org/0000-0001-9337-0411
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: SupervisionRole: Writing – original draftRole:
Writing – review & editing
Giovanni Bosco: Role: Editor
Journal
Journal ID (nlm-ta): PLoS Genet
Journal ID (iso-abbrev): PLoS Genet
Journal ID (publisher-id): plos
Title:
PLOS Genetics
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7390
ISSN
(Electronic):
1553-7404
Publication date
(Electronic):
21
September
2023
Publication date Collection:
September
2023
Volume: 19
Issue: 9
Electronic Location Identifier: e1010893
Affiliations
[1
]
Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University
College London, London, United Kingdom
[2
]
Department of Neuroscience and Biomedical Neuroscience Institute, Faculty of Medicine,
Universidad de Chile, Santiago, Chile
[3
]
UK Dementia Research Institute at UCL, Cruciform Building, London, United Kingdom
[4
]
Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology,
London, United Kingdom
Geisel School of Medicine at Dartmouth, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
[¤]
Current address: The Francis Crick Institute, London, United Kingdom
Author information
Article
Publisher ID:
PGENETICS-D-23-00755
DOI: 10.1371/journal.pgen.1010893
PMC ID: 10513295
PubMed ID: 37733679
SO-VID: 57eaa22c-700c-4d9c-baa2-6f24d6a296bc
Copyright © © 2023 Xu et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 7
July
2023
Date
accepted
: 29
July
2023
Page count
Figures: 6,
Tables: 2,
Pages: 25
Funding
Funded by:
ARUK
Award ID: ARUK-SRF2018A-003
Award Recipient
:
ORCID: https://orcid.org/0000-0001-9337-0411
Teresa Niccoli
Funded by:
ARUK
Award ID: ARUK-PG2016A-6
Award Recipient
:
Adrian M. Isaacs
Funded by:
Medical Research Council UK
Award ID: MR/V003585/1
Award Recipient
:
ORCID: https://orcid.org/0000-0001-9337-0411
Teresa Niccoli
Funded by:
ALZHEIMER'S SOCIETY
Award ID: AS-PhD-19b-015
Award Recipient
:
ORCID: https://orcid.org/0000-0001-9337-0411
Teresa Niccoli
Funded by:
funder-id http://dx.doi.org/10.13039/100010661, Horizon 2020 Framework Programme;
Award ID: 648716 – C9ND
Award Recipient
:
Adrian M. Isaacs
Funded by:
funder-id http://dx.doi.org/10.13039/501100017510, UK Dementia Research Institute;
Award Recipient
:
Adrian M. Isaacs
Funded by:
FONDECYT-Iniciación
Award ID: 11200477
Award Recipient
:
ORCID: https://orcid.org/0000-0002-9441-2211
Andrés González-Gutiérrez
Funded by:
FONDECYT Regular
Award ID: 1210586
Award Recipient
:
ORCID: https://orcid.org/0000-0002-0257-146X
Jimena Sierralta
This work was supported by the ARUK Senior Fellowship ARUK-SRF2018A-003 (TN), ARUK-PG2016A-6
(AMI), MRC grant MR/V003585/1 (TN), the Alzheimer’s Society Studentship (550(AS-PhD-19b-015))
(to TN), the European Research Council (ERC) under the European Union’s Horizon 2020
research and innovation programme (648716 – C9ND) (AMI) and the UK Dementia Research
Institute (AMI), which receives its funding from UK DRI Ltd, funded by the UK Medical
Research Council, Alzheimer's Society and Alzheimer's Research UK. FONDECYT-Iniciación
11200477 (to AGG) and FONDECYT Regular 1210586 (to JS). The funders had no role in
study design, data collection and analysis, decision to publish, or preparation of
the manuscript.
Categories
Subject:
Research Article
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Acids
Subject:
Ketones
Subject:
Pyruvate
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Death
Subject:
Autophagic Cell Death
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Neurons
Subject:
Biology and Life Sciences
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Neuroscience
Subject:
Cellular Neuroscience
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Neurons
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Biology and Life Sciences
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Biochemistry
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Metabolism
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Carbohydrate Metabolism
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Glucose Metabolism
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Medicine and Health Sciences
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Mental Health and Psychiatry
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Dementia
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Alzheimer's Disease
Subject:
Medicine and Health Sciences
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Neurology
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Dementia
Subject:
Alzheimer's Disease
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Neurodegenerative Diseases
Subject:
Alzheimer's Disease
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Neurodegenerative Diseases
Subject:
Alzheimer's Disease
Subject:
Biology and Life Sciences
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Toxicology
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Toxicity
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Medicine and Health Sciences
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Pathology and Laboratory Medicine
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Toxicology
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Toxicity
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Medicine and Health Sciences
Subject:
Mental Health and Psychiatry
Subject:
Dementia
Subject:
Frontotemporal Dementia
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Dementia
Subject:
Frontotemporal Dementia
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Epigenetics
Subject:
RNA interference
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Gene expression
Subject:
RNA interference
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Genetic interference
Subject:
RNA interference
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
RNA
Subject:
RNA interference
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