Effects of MICU1-Mediated Mitochondrial Calcium Uptake on Energy Metabolism and Quality of Vitrified-Thawed Mouse Metaphase II Oocytes.

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Abstract

Oocyte vitrification has been widely used in the treatment of infertility and fertility preservation. However, vitrification-induced mitochondrial damage adversely affects oocyte development. Several studies have reported that mitochondrial calcium uptake protein 1 (MICU1) regulates the uptake of mitochondrial calcium by the mitochondrial calcium uniporter (MCU) and subsequently controls aerobic metabolism and oxidative stress in mitochondria, but research considering oocytes remains unreported. We evaluated whether the addition of MICU1 modulators enhances mitochondrial activity, pyruvate metabolism, and developmental competence after warming of MII oocytes.

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Journal

Journal ID (iso-abbrev): Int J Mol Sci

Title: International journal of molecular sciences

Publisher: MDPI AG

ISSN (Electronic): 1422-0067

ISSN (Print): 1422-0067

Publication date (Electronic): Aug 03 2022

Volume: 23

Issue: 15

Affiliations

[1 ] Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling 712100, China.

Article

Publisher Item ID: ijms23158629

DOI: 10.3390/ijms23158629

PMC ID: 9368797

PubMed ID: 35955764

SO-VID: 57c268a4-8083-497e-9b79-24f491a1b9e6

History

Keywords: MICU1,pyruvate dehydrogenase,oocyte vitrification,mitochondria

Data availability:

Keywords: MICU1, pyruvate dehydrogenase, oocyte vitrification, mitochondria

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