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      Digital calibration method to enable depth-resolved all-fiber polarization sensitive optical coherence tomography with an arbitrary input polarization state

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      1 , 1 , 2 , 1 , *
      Biomedical Optics Express
      Optica Publishing Group

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          Abstract

          We present a fully integrated depth-resolved all fiber-based polarization sensitive optical coherence tomography (PSOCT). In contrast to conventional fiber-based PSOCT systems, which require additional modules to generate two or more input polarization states, or a pre-adjustment procedure to generate a circularly polarized light, the proposed all-fiber PSOCT system can provide depth-resolved birefringent imaging using an arbitrary single input polarization state. Utilizing the discrete differential geometry (DDG)-based polarization state tracing (PST) method, combined with several geometric rotations and transformations in the Stokes space, two problems induced by the optical fibers can be mitigated: 1) The change in the polarization state introduced by the optical fibers can be effectively compensated using a calibration target at the distal end of the probe, and the computations of the local axis orientation and local phase retardation can be achieved with a single arbitrary input polarization state, eliminating the need for a pre-defined input polarization state, allowing a flexible system design and user-friendly experimental procedure; 2) The polarization mode dispersion (PMD) induced by the optical fibers can be compensated digitally without the requirement of additional input polarization states, providing an accurate PSOCT imaging result. To demonstrate the performance of the proposed method, the depth resolved PSOCT results of a plastic phantom and in vivo skin imaging are obtained using the proposed all-fiber PSOCT system.

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          Most cited references27

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          Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography.

          Using a low-coherence Michelson interferometer, we measure two-dimensional images of optical birefringence in bovine tendon as a function of depth. Polarization-sensitive detection of the signal formed by interference of backscattered light from the sample and a mirror in the reference arm give the optical phase delay between light that is propagating along the fast and slow axes of the birefringent tendon. Images showing the change in birefringence in response to laser irradiation are presented. The technique permits rapid noncontact investigation of tissue structural properties through two-dimensional imaging of birefringence.
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            Review of polarization sensitive optical coherence tomography and Stokes vector determination.

            Polarization sensitive optical coherence tomography (PS-OCT) provides depth resolved measurements of the polarization state of light reflected from turbid media such as tissue. The theory and calculation of the Stokes vector of light reflected from turbid media is described and application of PS-OCT to contemporary biomedical imaging problems is given. Measurement of the depth resolved Stokes parameters allows determination of the degree of polarization and optical axis orientation in turbid media that can be modeled as a linear retarder. Effect of multiple scattering and speckle on the accuracy and noise of the computed Stokes parameters is discussed. Future directions for development of PS-OCT instrumentation for biological and medical applications is given.
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              Spectral binning for mitigation of polarization mode dispersion artifacts in catheter-based optical frequency domain imaging.

              Polarization mode dispersion (PMD) has been recognized as a significant barrier to sensitive and reproducible birefringence measurements with fiber-based, polarization-sensitive optical coherence tomography systems. Here, we present a signal processing strategy that reconstructs the local retardation robustly in the presence of system PMD. The algorithm uses a spectral binning approach to limit the detrimental impact of system PMD and benefits from the final averaging of the PMD-corrected retardation vectors of the spectral bins. The algorithm was validated with numerical simulations and experimental measurements of a rubber phantom. When applied to the imaging of human cadaveric coronary arteries, the algorithm was found to yield a substantial improvement in the reconstructed birefringence maps.
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                Author and article information

                Journal
                Biomed Opt Express
                Biomed Opt Express
                BOE
                Biomedical Optics Express
                Optica Publishing Group
                2156-7085
                24 April 2024
                01 May 2024
                : 15
                : 5
                : 3329-3343
                Affiliations
                [1 ]Department of Bioengineering, University of Washington , 3720 15th Ave NE, Seattle, Washington 98195, USA
                [2 ]Department of Ophthalmology, University of Washington , 750 Republican St., Seattle, Washington 98195, USA
                Author notes
                Author information
                https://orcid.org/0000-0001-5169-8822
                Article
                517826
                10.1364/BOE.517826
                11161387
                38855689
                57473aa6-a270-4356-8768-5988ad2783e4
                © 2024 Optica Publishing Group

                https://doi.org/10.1364/OA_License_v2#VOR-OA

                © 2024 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement

                History
                : 05 January 2024
                : 03 April 2024
                : 04 April 2024
                Funding
                Funded by: Washington Research Foundation 10.13039/100001906
                Categories
                Article

                Vision sciences
                Vision sciences

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