Research on the Balance of Thiol-Disulfide in Blood Serum in Women with Telogen Effluvium

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Abstract

Backgrounds:

Telogen effluvium (TE) is the most common reason for hair loss in humans. Although the exact etiopathogenesis of TE has not been revealed clearly and completely, multifactorial etiologies are to be blamed. In recent years, since oxidative stress (OS) has been shown to play an important role in the etiopathogenesis of so many diseases, the effects of OS on several skin diseases are researched and analyzed. Thiols are antioxidant components that include sulfur group, and the balance of thiol-disulfide has an important role in the formation and prevention of OS. This balance is destroyed in many diseases and its effect on TE is not clearly understood yet.

Objectives:

In this study, we aimed to search the thiol–disulfide balance that could reveal OS in patients with TE.

Materials and Methods:

Fifty-two patients with TE and control group of 46 persons were included in the study. Native thiol, disulfide, and total thiol levels were evaluated by a new, automatic spectrophotometric method. Disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol rates were calculated.

Results:

There was no statistical difference between TE patients and control group in terms of native thiol, disulfide, and total thiol levels. Thiol–disulfide balance was fixed and not affected in TE patients.

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Most cited references 41

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Oxidative stress in the pathogenesis of skin disease.

David R. Bickers, Mohammad Athar (2006)

Skin is the largest body organ that serves as an important environmental interface providing a protective envelope that is crucial for homeostasis. On the other hand, the skin is a major target for toxic insult by a broad spectrum of physical (i.e. UV radiation) and chemical (xenobiotic) agents that are capable of altering its structure and function. Many environmental pollutants are either themselves oxidants or catalyze the production of reactive oxygen species (ROS) directly or indirectly. ROS are believed to activate proliferative and cell survival signaling that can alter apoptotic pathways that may be involved in the pathogenesis of a number of skin disorders including photosensitivity diseases and some types of cutaneous malignancy. ROS act largely by driving several important molecular pathways that play important roles in diverse pathologic processes including ischemia-reperfusion injury, atherosclerosis, and inflammatory responses. The skin possesses an array of defense mechanisms that interact with toxicants to obviate their deleterious effect. These include non-enzymatic and enzymatic molecules that function as potent antioxidants or oxidant-degrading systems. Unfortunately, these homeostatic defenses, although highly effective, have limited capacity and can be overwhelmed thereby leading to increased ROS in the skin that can foster the development of dermatological diseases. One approach to preventing or treating these ROS-mediated disorders is based on the administration of various antioxidants in an effort to restore homeostasis. Although many antioxidants have shown substantive efficacy in cell culture systems and in animal models of oxidant injury, unequivocal confirmation of their beneficial effects in human populations has proven elusive.

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A novel and automated assay for thiol/disulphide homeostasis.

Ozcan Erel, Salim Neselioglu (2014)

To develop a novel and automated assay determining plasma thiol/disulphide homeostasis, which consists of thiol-disulphide exchanges.

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The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress.

Jorge Limón-Pacheco, María Gonsebatt (2009)

In aerobic organisms, oxygen is essential for efficient energy production but paradoxically, produces chronic toxic stress in cells. Diverse protective systems must exist to enable adaptation to oxidative environments. Oxidative stress (OS) results when production of reactive oxidative species (ROS) exceeds the capacity of cellular antioxidant defenses to remove these toxic species. Epidemiological and clinical studies have linked environmental factors such as diet and lifestyle to cancer, diabetes, atherosclerosis, and neurodegenerative disorders. All of these conditions, as well as the aging process, are associated with OS due to elevation of ROS or insufficient ROS detoxification. Many environmental pollutants engage signaling pathways that are activated in response to OS. The same sequences of events are also associated with the etiology and early pathology of many chronic diseases. Investigations of oxidative responses in different in vivo models suggest that, in complex organisms such as mammals, organs and tissues contain distinct antioxidant systems, and this may form the basis for differential susceptibility to environmental toxic agents Thus, understanding the pathways leading to the induction of antioxidant responses will enable development of strategies to protect against oxidative damage. We shall review evidence of organ-specific antioxidant responses elicited by environmental pollutants in humans and animal models.

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Author and article information

Journal

Journal ID (nlm-ta): Int J Trichology

Journal ID (iso-abbrev): Int J Trichology

Journal ID (publisher-id): IJT

Title: International Journal of Trichology

Publisher: Medknow Publications & Media Pvt Ltd (India )

ISSN (Print): 0974-7753

ISSN (Electronic): 0974-9241

Publication date (Print): Jan-Feb 2019

Volume: 11

Issue: 1

Pages: 20-25

Affiliations

[1]Department of Dermatology, Atatürk Training and Research Hospital, Ankara, Turkey

[1 ]Department of Dermatology, Yildirim Beyazit University, School of Medicine, Ankara, Turkey

[2 ]Department of Biochemistry, Atatürk Training and Research Hospital, Ankara, Turkey

Author notes

Address for correspondence: Dr. Ayşe Akbaş, Department of Dermatology, Ataturk Training and Research Hospital, Bilkent 06800, Ankara, Turkey. E-mail: ayseakbas62@ 123456gmail.com

Article

Publisher ID: IJT-11-20

DOI: 10.4103/ijt.ijt_78_17

PMC ID: 6385515

SO-VID: 54e5b8a6-0ea4-47ee-9d39-5b8d077c75dd

License:

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Research on the Balance of Thiol-Disulfide in Blood Serum in Women with Telogen Effluvium

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Abstract

Backgrounds:

Objectives:

Materials and Methods:

Results:

Related collections

Stress signalling in stem cells

Most cited references 41

Oxidative stress in the pathogenesis of skin disease.

A novel and automated assay for thiol/disulphide homeostasis.

The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress.

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