LPS/TLR4 signal transduction pathway.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Cytokine

Title: Cytokine

Publisher: Elsevier BV

ISSN (Electronic): 1096-0023

ISSN (Print): 1043-4666

Publication date (Electronic): May 2008

Volume: 42

Issue: 2

Affiliations

[1 ] The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1.

[2 ] The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1. Electronic address: wyeh38@gmail.com.

[3 ] The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1; Department of Immunology, University of Toronto, Toronto, Ont., Canada M5S1A8. Electronic address: pohashi@uhnres.utoronto.ca.

Article

Publisher Item ID: S1043-4666(08)00007-0

DOI: 10.1016/j.cyto.2008.01.006

PubMed ID: 18304834

SO-VID: 4a27a21a-4304-4d8e-9be2-91f43d9831db

History

Data availability:

Comments

Comment on this article

scite_

Cited by 973

See all cited by

- Version 1