Long-Lasting In Situ Forming Implant Loaded with Bupivacaine: Investigation on Polymeric and Non-Polymeric Carrier and Solvent Effect.

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Abstract

Typically, in situ forming implants utilize Poly (lactide- co- glycolide) (PLGA) as carrier and N-methyl-2-pyrrolidone (NMP) as solvent. However, it is essential to develop different carriers to release various drugs in a controlled and sustained manner with economic and safety considerations.

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Author and article information

Journal

Journal ID (iso-abbrev): Curr Drug Deliv

Title: Current drug delivery

Publisher: Bentham Science Publishers Ltd.

ISSN (Electronic): 1875-5704

ISSN (Print): 1567-2018

Publication date (Electronic): 2022

Volume: 19

Issue: 1

Affiliations

[1 ] Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, Tehran, Iran.

Article

Publisher Item ID: CDD-EPUB-116211

DOI: 10.2174/1567201818666210617102634

PubMed ID: 34139983

SO-VID: 453bf332-3f22-4936-a0c4-7722e266b7c5

History

Keywords: drug delivery systems,local anesthetic,in situ forming implant,bioavailability,SAIB,PLGA

Data availability:

Keywords: drug delivery systems, local anesthetic, in situ forming implant, bioavailability, SAIB, PLGA

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