Neutrophil Percentage as a Potential Biomarker of Acute Kidney Injury Risk and Short-Term Prognosis in Patients with Acute Myocardial Infarction in the Elderly

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Abstract

Objective

This study aimed to explore the association of preoperative neutrophil percentage (NEUT%) with the risk of acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) having undergone coronary interventional therapy.

Methods

A single-center, retrospective and observational study was conducted. From December 2012 to June 2021, patients with AMI were enrolled and divided into AKI group and non-AKI group. The NEUT% in the two groups was compared. The association between NEUT% with the risk of post-AMI AKI was analyzed by univariate and multivariable logistic regression. Kaplan-Meier survival curve was drawn to evaluate the prognostic ability of NEUT% for short-term all-cause death following AMI.

Results

A total of 3001 consecutive patients were enrolled with an average age of 64.38 years. AKI occurred in 327 (10.9%) patients. The NEUT% was higher in the AKI group than in the non-AKI group ([76.65±11.43]% versus [73.22±11.83]%, P<0.001). NEUT% was also identified as an independent risk factor for AKI in AMI patients after adjustment (OR=1.021, 95% CI: 1.010–1.033, P < 0.001). Compared with those at the lowest quartile of NEUT%, the patients at quartiles 2–4 had a higher risk of AKI ( P for trend = 0.003). The odds of AKI increased by 29.0% as NEUT% increased by 1 standard deviation (OR=1.290, 95% CI: 1.087–1.531, P = 0.004). After a median of 35 days follow-up, 93 patients died. Patients with a higher NEUT% presented a higher risk of all-cause death after AMI (Log rank: χ ² =24.753, P<0.001).

Conclusion

In AMI patients, the peripheral blood NEUT% was positively associated with the odds of AKI and short-term all-cause mortality. NEUT% may provide physicians with more information about disease development and prognosis.

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Most cited references 53

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Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

Gregory A Roth, George A Mensah, Catherine O. Johnson … (2021)

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases.

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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.

Paul M Ridker, Brendan M. Everett, Tom Thuren … (2017)

Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved.

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Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Maigeng Zhou, Haidong Wang, Xinying Zeng … (2019)

Summary Background Public health is a priority for the Chinese Government. Evidence-based decision making for health at the province level in China, which is home to a fifth of the global population, is of paramount importance. This analysis uses data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to help inform decision making and monitor progress on health at the province level. Methods We used the methods in GBD 2017 to analyse health patterns in the 34 province-level administrative units in China from 1990 to 2017. We estimated all-cause and cause-specific mortality, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life-years (DALYs), summary exposure values (SEVs), and attributable risk. We compared the observed results with expected values estimated based on the Socio-demographic Index (SDI). Findings Stroke and ischaemic heart disease were the leading causes of death and DALYs at the national level in China in 2017. Age-standardised DALYs per 100 000 population decreased by 33·1% (95% uncertainty interval [UI] 29·8 to 37·4) for stroke and increased by 4·6% (–3·3 to 10·7) for ischaemic heart disease from 1990 to 2017. Age-standardised stroke, ischaemic heart disease, lung cancer, chronic obstructive pulmonary disease, and liver cancer were the five leading causes of YLLs in 2017. Musculoskeletal disorders, mental health disorders, and sense organ diseases were the three leading causes of YLDs in 2017, and high systolic blood pressure, smoking, high-sodium diet, and ambient particulate matter pollution were among the leading four risk factors contributing to deaths and DALYs. All provinces had higher than expected DALYs per 100 000 population for liver cancer, with the observed to expected ratio ranging from 2·04 to 6·88. The all-cause age-standardised DALYs per 100 000 population were lower than expected in all provinces in 2017, and among the top 20 level 3 causes were lower than expected for ischaemic heart disease, Alzheimer's disease, headache disorder, and low back pain. The largest percentage change at the national level in age-standardised SEVs among the top ten leading risk factors was in high body-mass index (185%, 95% UI 113·1 to 247·7]), followed by ambient particulate matter pollution (88·5%, 66·4 to 116·4). Interpretation China has made substantial progress in reducing the burden of many diseases and disabilities. Strategies targeting chronic diseases, particularly in the elderly, should be prioritised in the expanding Chinese health-care system. Funding China National Key Research and Development Program and Bill & Melinda Gates Foundation.

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Author and article information

Journal

Journal ID (nlm-ta): Clin Interv Aging

Journal ID (iso-abbrev): Clin Interv Aging

Journal ID (publisher-id): cia

Title: Clinical Interventions in Aging

Publisher: Dove

ISSN (Print): 1176-9092

ISSN (Electronic): 1178-1998

Publication date (Electronic): 18 March 2024

Publication date Collection: 2024

Volume: 19

Pages: 503-515

Affiliations

[1 ]Department of Cardiology, the Affiliated Changzhou Second People’s Hospital of Nanjing Medical University , Changzhou, Jiangsu, 213000, People’s Republic of China

[2 ]Department of Cardiology, the Affiliated Wuxi People’s Hospital of Nanjing Medical University , Wuxi, Jiangsu, 214023, People’s Republic of China

[3 ]Department of Cardiovascular Surgery, the First Affiliated Hospital of Wannan Medical College , Wuhu, Anhui, 241000, People’s Republic of China

Author notes

Correspondence: Qingjie Wang; Ling Sun, Department of Cardiology, the Affiliated Changzhou Second People’s Hospital of Nanjing Medical University , 29 Xinglong Alley, Changzhou, Jiangsu, 213003, People’s Republic of China, Email wang-qingjie@hotmail.com; sunling85125@hotmail.com

[*]

These authors contributed equally to this work

Author information

Qianwen Chen http://orcid.org/0000-0003-2579-8322

Qingqing Gu http://orcid.org/0000-0001-9399-278X

Dabei Cai http://orcid.org/0000-0001-6898-0664

Yu Wang http://orcid.org/0000-0002-1872-3931

Ling Sun http://orcid.org/0000-0001-6444-9470

Article

Publisher ID: 455588

DOI: 10.2147/CIA.S455588

PMC ID: 10959300

PubMed ID: 38525316

SO-VID: 4476414a-5e2c-4cc6-950a-da832a192321

License:

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

History

Date received : 18 December 2023

Date accepted : 12 March 2024

Page count

Figures: 4, Tables: 9, References: 53, Pages: 13

Funding

Funded by: National Natural Science Foundation of China, open-funder-registry 10.13039/501100001809;

Funded by: Natural Science Foundation of Jiangsu Province, open-funder-registry 10.13039/501100004608;

Funded by: China Postdoctoral Science Funding Program;

Funded by: Changzhou High-Level Medical Talents Training Project;

Funded by: the Technology Development Fund of Nanjing Medical University;

Funded by: Major Research plan of Changzhou Health Commission of Jiangsu Province of China;

Funded by: Changzhou Sci&Tech Program;

Funded by: Major Research plan of Wannan Medical College;

Funded by: Major Research plan of Anhui Education Commission;

This study was supported by National Natural Science Foundation of China (Grant No.82270328), Natural Science Foundation of Jiangsu Province (BK20221229), China Postdoctoral Science Funding Program (2022M720544), Changzhou High-Level Medical Talents Training Project (2022CZBJ054, 2022CZBJ053), the Technology Development Fund of Nanjing Medical University (NMUB2020069), Major Research plan of Changzhou Health Commission of Jiangsu Province of China (ZD202215), Changzhou Sci&Tech Program (CE20225051). Major Research plan of Wannan Medical College (WK2022F19) and Major Research plan of Anhui Education Commission (KJ2021A0822).

Neutrophil Percentage as a Potential Biomarker of Acute Kidney Injury Risk and Short-Term Prognosis in Patients with Acute Myocardial Infarction in the Elderly

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Abstract

Objective

Methods

Results

Conclusion

Related collections

Karger: Nephrology

Most cited references 53

Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.

Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

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