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      Endoscopic and External Surgical Approach to Paranasal Sinus Mucocele

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          Abstract

          Mucoceles of the paranasal sinuses are not common, but usually present as cystic lesions causing facial asymmetry requiring surgery. Hitherto surgical attempts at excision were external surgical approaches with the use of stents to drain the frontoethmoidal sinus, if they were the principal sinus involved, for a variable period. Recent advances in endoscopic sinus surgery have made the endoscopic approach to surgically manage paranasal sinus mucoceles the new trend. A total of 18 patients were seen over a ten-year period with paranasal sinus mucocele; 14 cases were managed through the external approach, while four were consecutively managed endoscopically. The endoscopic approach in the surgical management of mucoceles of the paranasal sinuses and the external approach are discussed in this article with the intent of showing the advantages of the two approaches, with more emphasis on the endoscopic approach and caution that should the endoscopic approach prove difficult, reversal to the external approach should be undertaken immediately, so as to avoid unnecessary complications.

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          Involvement of cytokines and vascular adhesion receptors in the pathology of fronto-ethmoidal mucocoeles.

          Fronto-ethmoidal mucocoeles have the capacity to destroy bone. Sinus lining tissue has been obtained at surgery from patients with mucocoeles, from those with chronic sinusitis undergoing endoscopic sinus surgery and from patients undergoing craniofacial resection. Tissues have been frozen, sectioned, and subjected to immunohistochemical examination with monospecific antibodies for the presence of the potent osteolytic cytokines interleukins-1 and -6 and tumour necrosis factor alpha. In addition, the chemotactic intercrine--interleukin-8 was investigated. The presence of the cytokine-inducible vascular endothelial adhesion receptors--Inter-Cellular Adhesion Molecule (ICAM)-1 and E-Selectin (also known as Endothelial Leukocyte Adhesion Molecule--ELAM) was also determined. Normal sinus tissue showed no immunoreactivity with the antibodies to these various moieties. Surprisingly, only a small proportion of tissues from patients with chronic sinusitis showed the presence of cytokines or vascular adhesion receptors. In contrast, all specimens of fronto-ethmoidal mucocoeles showed positive staining for IL-1 alpha and beta and for ICAM-1 and E-selectin. IL-1 immunostaining was restricted to the epithelial cell population not being found in infiltrating leukocytes. In 40% of mucocoeles infiltrating macrophage-like cells showed the presence of tumour necrosis factor alpha. The presence of the potent osteolytic cytokine--IL-1 in all specimens of fronto-ethmoidal mucocoeles coupled to the finding of the IL-1-inducible adhesion molecules ICAM-1 and E-Selectin argues strongly that IL-1 is released from the epithelial cells and that this cytokine may be the factor causing the erosion of bone overlying the expanding mucocoele. The nature of the signals inducing cytokine synthesis remain, however, unidentified.
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            Fronto-ethmoidal mucocoeles: a histopathological analysis.

            From a series of 118 fronto-ethmoidal mucocoeles, 40 specimens have been submitted to detailed histological analysis. The frequency of each epithelial and sub-epithelial component is considered and reveals features which support a dynamic theory of bone resorption and formation rather than that of pressure erosion in the pathogenesis of mucocoeles.
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              Endoscopic management of paranasal sinus mucocoeles.

              V Lund (1997)
              Mucocoeles of the paranasal sinuses are relatively uncommon and in the past have been generally treated by an external surgical approach. Forty-eight mucocoeles in the frontal, fronto-ethmoidal and sphenoidal sinuses have been treated during the last five years, 20 by an entirely endonasal endoscopic approach and 28 by a combination of an external procedure and an endoscopic approach. There were no recurrences in the endoscopic group, with a mean follow-up of 34 months whilst three recurrences occurred in the combined external and endoscopic group which had a mean follow-up of 44 months. This may reflect the complexity and severity of concomitant disease. If a wide marsupialization can be achieved by an entirely endoscopic approach there are a number of advantages, notably a lack of facial scarring in children and young adults.
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                Author and article information

                Journal
                J Surg Tech Case Rep
                JSTCR
                Journal of Surgical Technique and Case Report
                Medknow Publications (India )
                2006-8808
                0976-2825
                Jan-Jun 2010
                : 2
                : 1
                : 49-53
                Affiliations
                [1] Department of Otorhinolaryngology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria
                Author notes
                Address for correspondence: Dr. K. R. Iseh, Department of Otorhinolaryngology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. E-mail: frobih@ 123456yahoo.com
                Article
                JSTCR-2-49
                10.4103/2006-8808.63728
                3214493
                22091333
                417c3bb3-3275-4cd5-bcb1-a42fd6ce97bf
                Copyright: © Journal of Surgical Technique and Case Report

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Categories
                How I Do It

                Surgery
                external approach,paranasal sinus mucoceles,endoscopic approach
                Surgery
                external approach, paranasal sinus mucoceles, endoscopic approach

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