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      Fabrication and Characterization of Silk Fibroin/Curcumin Sustained-Release Film

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          Abstract

          In the present work, a sustained-release film composed of silk fibroin (SF), curcumin (Cur), glutaraldehyde (GA), and glycerol (Gly) was prepared successfully for wound dressings. Features relevant to wound dressings of SF/Gly/GA/Cur film were assessed. Physical and chemical properties of the fabricated materials were also characterized. The results showed that the prepared SF/Gly/GA/Cur film demonstrated a good sustained-release performance, flexibility, and gas permeability. In addition, it was found that the prepared SF/Gly/GA/Cur film possessed the capability to effectively inhibit the growth of bacteria and prevent bacterial penetration with a suitable water vapor transmission rate. Furthermore, the prepared composite film was non-cytotoxic, which makes it an ideal material for wound dressings.

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          Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics.

          Dae-Hyeong Kim, Jonathan Viventi, Jason J Amsden … (2010)
          Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain/machine interfaces. This article describes a material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin. Mounting such devices on tissue and then allowing the silk to dissolve and resorb initiates a spontaneous, conformal wrapping process driven by capillary forces at the biotic/abiotic interface. Specialized mesh designs and ultrathin forms for the electronics ensure minimal stresses on the tissue and highly conformal coverage, even for complex curvilinear surfaces, as confirmed by experimental and theoretical studies. In vivo, neural mapping experiments on feline animal models illustrate one mode of use for this class of technology. These concepts provide new capabilities for implantable and surgical devices.
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            The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms

            T. Velnar, T. Bailey, V Smrkolj (2009)
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              Water-insoluble silk films with silk I structure.

              Kayla Kaplan, Xiaoqin Wang, R.-S. Lu … (2010)
              Water-insoluble regenerated silk materials are normally produced by increasing the beta-sheet content (silk II). In the present study water-insoluble silk films were prepared by controlling the very slow drying of Bombyx mori silk solutions, resulting in the formation of stable films with a predominant silk I instead of silk II structure. Wide angle X-ray scattering indicated that the silk films stabilized by slow drying were mainly composed of silk I rather than silk II, while water- and methanol-annealed silk films had a higher silk II content. The silk films prepared by slow drying had a globule-like structure at the core surrounded by nano-filaments. The core region was composed of silk I and silk II, surrounded by hydrophilic nano-filaments containing random turns and alpha-helix secondary structures. The insoluble silk films prepared by slow drying had unique thermal, mechanical and degradative properties. Differential scanning calorimetry results revealed that silk I crystals had stable thermal properties up to 250 degrees C, without crystallization above the T(g), but degraded at lower temperatures than silk II structure. Compared with water- and methanol-annealed films the films prepared by slow drying had better mechanical ductility and were more rapidly enzymatically degraded, reflecting the differences in secondary structure achieved via differences in post processing of the cast silk films. Importantly, the silk I structure, a key intermediate secondary structure for the formation of mechanically robust natural silk fibers, was successfully generated by the present approach of very slow drying, mimicking the natural process. The results also point to a new mode of generating new types of silk biomaterials with enhanced mechanical properties and increased degradation rates, while maintaining water insolubility, along with a low beta-sheet content. Copyright 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Materials (Basel)
                Journal ID (iso-abbrev): Materials (Basel)
                Journal ID (publisher-id): materials
                Title: Materials
                Publisher: MDPI
                ISSN (Electronic): 1996-1944
                Publication date (Electronic): 14 October 2019
                Publication date Collection: October 2019
                Volume: 12
                Issue: 20
                Electronic Location Identifier: 3340
                Affiliations
                State Key Laboratory of Silkworm Genome Biology, College of Biotechnology, Southwest University, Chongqing 400715, China; c618@ 123456email.swu.edu.cn (Z.C.); dsbrodus@ 123456gmail.com (H.B.); liangjianwei0504@ 123456163.com (J.L.); 2008uky@ 123456gmail.com (S.X.); XZH239@ 123456uky.edu (G.C.)
                Author notes
                [* ]Correspondence: xzhang@ 123456swu.edu.cn (X.Z.); xzhan21@ 123456ilstu.edu (Y.Z.); Tel.: +86-1592-281-5612 (X.Z.)
                Author information
                https://orcid.org/0000-0002-1993-2970
                Article
                Publisher ID: materials-12-03340
                DOI: 10.3390/ma12203340
                PMC ID: 6829413
                PubMed ID: 31614998
                SO-VID: 3eb8eb3e-4d5f-4f37-9ee2-3bde7e80dc88
                Copyright © © 2019 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 03 October 2019
                Date accepted : 11 October 2019
                Categories
                Subject: Article

                Keywords: silk fibroin,curcumin,sustained-release,antibacterial activity,cytotoxicity
                Data availability:
                Keywords: silk fibroin, curcumin, sustained-release, antibacterial activity, cytotoxicity

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