Multi-azole-resistant Aspergillus fumigatus in the environment in Tanzania.

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Abstract

Azole resistance in Aspergillus fumigatus isolates has been increasingly reported with variable prevalence worldwide and is challenging the effective management of aspergillosis. Here we report the coexistence of both TR₃₄/L98H and TR₄₆/Y121F/T289A resistance mechanisms in azole-resistant A. fumigatus (ARAF) isolates originating from Tanzania, Africa.

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Journal

Journal ID (iso-abbrev): J. Antimicrob. Chemother.

Title: The Journal of antimicrobial chemotherapy

ISSN (Electronic): 1460-2091

ISSN (Print): 0305-7453

Publication date (Electronic): Nov 2014

Volume: 69

Issue: 11

Affiliations

[1 ] Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India dranuradha@hotmail.com.

[2 ] Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.

[3 ] Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.

[4 ] Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands.

[5 ] Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands.

Article

Publisher Item ID: dku259

DOI: 10.1093/jac/dku259

PubMed ID: 25006238

SO-VID: 3aa62368-0d94-40d2-86ad-85aff1ec8c86

Copyright © © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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Keywords: Africa,azole-resistant A. fumigatus,microsatellite typing,resistance mechanisms

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Keywords: Africa, azole-resistant A. fumigatus, microsatellite typing, resistance mechanisms

Multi-azole-resistant Aspergillus fumigatus in the environment in Tanzania.

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