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      Nanomaterials: certain aspects of application, risk assessment and risk communication

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          Abstract

          Development and market introduction of new nanomaterials trigger the need for an adequate risk assessment of such products alongside suitable risk communication measures. Current application of classical and new nanomaterials is analyzed in context of regulatory requirements and standardization for chemicals, food and consumer products. The challenges of nanomaterial characterization as the main bottleneck of risk assessment and regulation are presented. In some areas, e.g., quantification of nanomaterials within complex matrices, the establishment and adaptation of analytical techniques such as laser ablation inductively coupled plasma mass spectrometry and others are potentially suited to meet the requirements. As an example, we here provide an approach for the reliable characterization of human exposure to nanomaterials resulting from food packaging. Furthermore, results of nanomaterial toxicity and ecotoxicity testing are discussed, with concluding key criteria such as solubility and fiber rigidity as important parameters to be considered in material development and regulation. Although an analysis of the public opinion has revealed a distinguished rating depending on the particular field of application, a rather positive perception of nanotechnology could be ascertained for the German public in general. An improvement of material characterization in both toxicological testing as well as end-product control was concluded as being the main obstacle to ensure not only safe use of materials, but also wide acceptance of this and any novel technology in the general public.

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          Most cited references136

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          Longitudinal unzipping of carbon nanotubes to form graphene nanoribbons.

          Graphene, or single-layered graphite, with its high crystallinity and interesting semimetal electronic properties, has emerged as an exciting two-dimensional material showing great promise for the fabrication of nanoscale devices. Thin, elongated strips of graphene that possess straight edges, termed graphene ribbons, gradually transform from semiconductors to semimetals as their width increases, and represent a particularly versatile variety of graphene. Several lithographic, chemical and synthetic procedures are known to produce microscopic samples of graphene nanoribbons, and one chemical vapour deposition process has successfully produced macroscopic quantities of nanoribbons at 950 degrees C. Here we describe a simple solution-based oxidative process for producing a nearly 100% yield of nanoribbon structures by lengthwise cutting and unravelling of multiwalled carbon nanotube (MWCNT) side walls. Although oxidative shortening of MWCNTs has previously been achieved, lengthwise cutting is hitherto unreported. Ribbon structures with high water solubility are obtained. Subsequent chemical reduction of the nanoribbons from MWCNTs results in restoration of electrical conductivity. These early results affording nanoribbons could eventually lead to applications in fields of electronics and composite materials where bulk quantities of nanoribbons are required.
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            Titanium dioxide nanoparticles in food and personal care products.

            Titanium dioxide is a common additive in many food, personal care, and other consumer products used by people, which after use can enter the sewage system and, subsequently, enter the environment as treated effluent discharged to surface waters or biosolids applied to agricultural land, incinerated wastes, or landfill solids. This study quantifies the amount of titanium in common food products, derives estimates of human exposure to dietary (nano-) TiO(2), and discusses the impact of the nanoscale fraction of TiO(2) entering the environment. The foods with the highest content of TiO(2) included candies, sweets, and chewing gums. Among personal care products, toothpastes and select sunscreens contained 1% to >10% titanium by weight. While some other crèmes contained titanium, despite being colored white, most shampoos, deodorants, and shaving creams contained the lowest levels of titanium (<0.01 μg/mg). For several high-consumption pharmaceuticals, the titanium content ranged from below the instrument detection limit (0.0001 μg Ti/mg) to a high of 0.014 μg Ti/mg. Electron microscopy and stability testing of food-grade TiO(2) (E171) suggests that approximately 36% of the particles are less than 100 nm in at least one dimension and that it readily disperses in water as fairly stable colloids. However, filtration of water solubilized consumer products and personal care products indicated that less than 5% of the titanium was able to pass through 0.45 or 0.7 μm pores. Two white paints contained 110 μg Ti/mg while three sealants (i.e., prime coat paint) contained less titanium (25 to 40 μg Ti/mg). This research showed that, while many white-colored products contained titanium, it was not a prerequisite. Although several of these product classes contained low amounts of titanium, their widespread use and disposal down the drain and eventually to wastewater treatment plants (WWTPs) deserves attention. A Monte Carlo human exposure analysis to TiO(2) through foods identified children as having the highest exposures because TiO(2) content of sweets is higher than other food products and that a typical exposure for a US adult may be on the order of 1 mg Ti per kilogram body weight per day. Thus, because of the millions of tons of titanium-based white pigment used annually, testing should focus on food-grade TiO(2) (E171) rather than that adopted in many environmental health and safety tests (i.e., P25), which is used in much lower amounts in products less likely to enter the environment (e.g., catalyst supports, photocatalytic coatings).
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              Comparative eco-toxicity of nanoscale TiO2, SiO2, and ZnO water suspensions.

              The potential eco-toxicity of nanosized titanium dioxide (TiO(2)), silicon dioxide (SiO(2)), and zinc oxide (ZnO) water suspensions was investigated using Gram-positive Bacillus subtilis and Gram-negative Escherichia coli as test organisms. These three photosensitive nanomaterials were harmful to varying degrees, with antibacterial activity increasing with particle concentration. Antibacterial activity generally increased from SiO(2) to TiO(2) to ZnO, and B. subtilis was most susceptible to their effects. Advertised nanoparticle size did not correspond to true particle size. Apparently, aggregation produced similarly sized particles that had similar antibacterial activity at a given concentration. The presence of light was a significant factor under most conditions tested, presumably due to its role in promoting generation of reactive oxygen species (ROS). However, bacterial growth inhibition was also observed under dark conditions, indicating that undetermined mechanisms additional to photocatalytic ROS production were responsible for toxicity. These results highlight the need for caution during the use and disposal of such manufactured nanomaterials to prevent unintended environmental impacts, as well as the importance of further research on the mechanisms and factors that increase toxicity to enhance risk management.
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                Author and article information

                Contributors
                peter.laux@bfr.bund.de
                Journal
                Arch Toxicol
                Arch. Toxicol
                Archives of Toxicology
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                0340-5761
                1432-0738
                22 December 2017
                22 December 2017
                2018
                : 92
                : 1
                : 121-141
                Affiliations
                [1 ]ISNI 0000 0000 8852 3623, GRID grid.417830.9, Department of Chemical and Product Safety, , German Federal Institute for Risk Assessment (BfR), ; Max-Dohrn-Strasse 8-10 10589 Berlin, Germany
                [2 ]ISNI 0000 0000 8852 3623, GRID grid.417830.9, Department of Food Safety, , German Federal Institute for Risk Assessment (BfR), ; Max-Dohrn-Strasse 8-10 10589 Berlin, Germany
                [3 ]ISNI 0000 0000 9191 9864, GRID grid.418009.4, Department of Inhalation Toxicology, , Fraunhofer-Institute for Toxicology and Experimental Medicine (ITEM), ; Nikolai Fuchs Strasse 1 30625 Hannover, Germany
                [4 ]ISNI 0000 0000 8852 3623, GRID grid.417830.9, Department of Risk Communication, , German Federal Institute for Risk Assessment (BfR), ; Max-Dohrn-Strasse 8-10 10589 Berlin, Germany
                [5 ]ISNI 0000 0001 0584 7022, GRID grid.15540.35, Laboratoire de Fougères, , French Agency for Food, Environmental and Occupational Health and Safety (ANSES), ; 10B Rue Claude Bourgelat 35306 Fougères Cedex, France
                [6 ]ISNI 0000 0004 0495 360X, GRID grid.424644.4, Fraunhofer Institute for Silicate Research ISC, ; Neunerplatz 2 97082 Würzburg, Germany
                [7 ]ISNI 0000 0004 0573 9904, GRID grid.418010.c, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, ; Auf Dem Aberg 1 57392 Schmallenberg, Germany
                [8 ]ISNI 0000 0004 0603 5458, GRID grid.71566.33, Division 1.1 Inorganic Trace Analysis, , Federal Institute for Materials Research and Testing (BAM), ; Richard-Willstaetter-Str. 11 12489 Berlin, Germany
                [9 ]OECD Environment, Health and Safety Division 2, rue Andre-Pascal 75775 Paris Cedex 16, France
                [10 ]ISNI 0000 0004 1758 4137, GRID grid.434554.7, Joint Research Centre (JRC) of the European Commission, Directorate Health, Consumers and Reference Materials, ; Via E. Fermi, 2749 21027 Ispra, Italy
                [11 ]ISNI 0000 0004 1792 4701, GRID grid.483440.f, Scientific Committee and Emerging Risks Unit, , European Food Safety Authority (EFSA), ; Via Carlo Magno 1a 43126 Parma, Italy
                [12 ]ISNI 0000 0000 9730 7658, GRID grid.466709.a, Fraunhofer Institute for Process Engineering and Packaging IVV, ; Giggenhauser Strasse 35 85354 Freising, Germany
                [13 ]ISNI 0000 0001 1945 4326, GRID grid.459551.9, Fraunhofer Institute for Systems and Innovation Research ISI, ; Breslauer Strasse 48 76139 Karlsruhe, Germany
                [14 ]ISNI 0000 0001 2034 8950, GRID grid.461622.5, Fraunhofer Institute for Ceramic Technologies and Systems IKTS, ; Winterbergstr. 28 01277 Dresden, Germany
                Author information
                http://orcid.org/0000-0002-0351-3392
                Article
                2144
                10.1007/s00204-017-2144-1
                5773666
                29273819
                350e3521-0a71-4fed-a99f-f8f7484b5583
                © The Author(s) 2017

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                : 6 October 2017
                : 13 December 2017
                Categories
                Review Article
                Custom metadata
                © Springer-Verlag GmbH Germany, part of Springer Nature 2018

                Toxicology
                nanomaterials,toxicity,ecotoxicity,standardization,exposure
                Toxicology
                nanomaterials, toxicity, ecotoxicity, standardization, exposure

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