- Record: found
- Abstract: not found
- Article: not found
Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic
January 2010
January 2010
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Aflatoxin B1 (AFB1) has been consistently shown to be a potent mutagen and is a liver
carcinogen in humans and a wide range of animal species. The Fisher rat appears to
be the most sensitive animal model. Dose-response modelling results in a BMDL(10)
of 250 ng/kg-bw/d. Estimates of mean dietary exposure estimates were 0.4 ng/kg-bw/d
and 2.6 ng/kg-bw/d, representing regions with low and high exposure, respectively.
The MOEs for mean exposure therefore range from 100 to 600.
Crown Copyright 2010. Published by Elsevier Ltd. All rights reserved.