Role of Additives during Deracemization Using Temperature Cycling

Abstract

Temperature cycling, alongside Viedma ripening, has been established as a reliable method for deracemizing racemic mixtures of chiral compounds that crystallize as a conglomerate. Here we report that the speed of temperature cycling can be increased by using chiral additives. We also demonstrate that the chirality of the additive determines the final enantiomeric state of the solid phase. Viedma ripening experiments using equivalent conditions, with and without chiral additives, are always found to be slower.

Abstract

Similar to previous Viedma ripening studies, the use of chiral additives can also increase the speed of deracemization using temperature cycling. Using equivalent conditions, Viedma ripening experiments are always found to be slower.