Progress in application of positron emission tomography/computed tomography (PET/CT) imaging in tumor screening

Abstract

Worldwide, the incidence of cancer is greatest in China. Tumor screening is effective to achieve early diagnosis, improve prognosis, increase the quality of life, and reduce mortality among cancer patients. Positron emission tomography/computed tomography (PET/CT) imaging provides metabolic data to support initial staging, treatment planning, and response evaluation in tumor screening, as well as tumor follow-up. The progressive integration of PET/CT imaging in radiotherapy has its basic principle in the biological heterogeneity of interand intra-tumor malignant lesions, and the radiation dose is required to be adjusted to achieve effective local tumor control among cancer patients. In addition, PET/CT imaging provides data on the biological features of tumor lesions, such as metabolism, hypoxia, and proliferation, which is useful to identify radiation-resistant regions and optimize treatment plans. These data are effective to reduce the uncertainty and variability in the anatomic description of tumor sites. This review summarizes the application of PET/CT imaging in common tumors.

Abstract

摘要： 我国是世界癌症发病最多的国家, 筛查可以实现肿瘤早期诊断、改善患者预后、提高生存质量、降低死亡率。正 电子发射断层扫描/计算机断层扫描(PET/CT)提供的代谢信息有助于肿瘤筛查初始分期、治疗计划、反应评估, 并在 较小程度上可用于肿瘤的随访; PET/CT 成像在放射治疗中的渐进式整合在肿瘤间和肿瘤内恶性病变的生物异质性中 具有其基本原理, 需要单独调整辐射剂量以获得癌症患者的有效局部肿瘤控制; PET/CT 提供有关肿瘤病变的生物学 特征(如代谢、缺氧和增殖)的信息, 可以识别放射性耐药区域并利用这些信息来优化治疗计划, PET/CT 减少了肿瘤 部位解剖学描绘的不确定性和可变性。本文主要就目前常见肿瘤在 PET/CT 研究中的应用进展进行综述。