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      The use of endocrine treatments to improve pregnancy rates in cattle

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      Reproduction, Fertility and Development
      CSIRO Publishing

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          Abstract

          Reproduction is critical for the success of both dairy and beef cattle production. Inadequate reproduction impairs profitability by compromising production, delaying genetic progress and increasing expenses. A major impediment to the use of artificial insemination (AI) is the ability to detect oestrus for optimum timing of breeding. However, increased understanding of the bovine oestrous cycle has led to the development of reproductive programmes that allow precise synchrony of follicle development, luteal regression and ovulation. The advent of timed-AI protocols revolutionised reproductive management in dairy and beef herds. It allows for AI at a more desired time post partum despite oestrous cyclicity. It also allows for pre-determined re-insemination of cows diagnosed as not pregnant. In subfertile cows, such as the post partum, anoestrous beef cow and the high-producing dairy cow, strategic hormone supplementation has been used to overcome hormone deficiencies and improve pregnancy rates. Several physiological windows have been identified to optimise fertility in synchronisation programmes and they include, but are not limited to, follicle turnover, synchrony of follicular development, length of dominance, progesterone concentrations during development of the ovulatory follicle, luteal regression, peri-ovulatory steroid concentrations, length of pro-oestrus, synchrony of ovulation and AI, and progesterone rise after ovulation.

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          Most cited references55

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          The effect of embryonic death rates in cattle on the efficacy of estrus synchronization programs.

          Reproductive failure in inseminated cattle results from poor fertilization and embryo survival. Recent studies utilizing dairy and beef cattle indicate that fertilization rates are higher for nulliparous dairy and beef heifers and nonlactating beef cows than lactating beef and dairy cows and nonlactating dairy cows. Several factors affect fertilization rates, but the greatest impact was observed for high producing cows under heat stress, when fertilization was only 55%. Once fertilization has occurred, the fate of a successful pregnancy is then determined by the survival of the embryo and fetus. Losses of pregnancy are characterized by early embryonic death, which occurs prior to the period of corpus luteum (CL) maintenance in the cow at days 15-17 of the cycle, and late embryonic death, which occurs from CL maintenance to the end of the differentiation stage, at approximately 42 days of gestation. After 50 days of gestation, pregnancy losses are less frequent and characterize fetal death. Most pregnancy losses occur prior to the period of maintenance of the CL, but in high producing lactating dairy cattle, substantial losses continue to occur up to 42-56 days after insemination. Several factors affect pregnancy losses in cattle, such as compromised oocytes, which result in poorly developed embryos incapable of cross-talking with the endometrial epithelial cells, to inadequate uterine environment and infectious agents resulting in death of the embryo from undernourishment. Recently, studies have indicated that anovulation/anestrous, the metabolic status of the animal, some dietary ingredients, as well as occurrence of diseases, predispose the cow to experience embryonic and fetal death. Although some insemination protocols might impact embryo survival, when timed AI has been implemented properly, it has not influenced embryonic or fetal death in cattle. Improvements in reproductive programs in the future will have to focus on enhancing fertilization rates and minimizing embryonic losses to optimize conception rates in dairy and beef cattle.
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            The use of hormonal treatments to improve reproductive performance of anestrous beef cattle in tropical climates.

            Most of the world's bovine herd is found in tropical regions. Bos indicus predominates, due to their adaptation to the climate and management conditions. Anestrous is the main factor that negatively affects reproductive performance of animals bred in these regions of the globe. Several factors affect postpartum anestrous, including suckling and maternal-offspring bond, and pre- and postpartum nutritional status. The short duration of estrus and the tendency to show estrus during the night, greatly affect the efficiency of artificial insemination (AI) programs in B. indicus cattle managed in tropical areas. Several restricted suckling or weaning procedures (temporary or permanent), and hormonal treatments have been used to induce ovulation and cyclicity in postpartum cows. Most hormonal treatments are based on progesterone/progestogen (P4) releasing devices associated with estradiol benzoate (EB), or a combination of GnRH/PGF(2alpha)/GnRH (Ovsynch). Treatments with GnRH/PGF(2alpha)/GnRH has presented inconsistent results, probably due to the variable number of cows in anestrous. Treatments using P4 devices and EB have resulted in apparently more consistent results than Ovsynch programs in B. indicus cattle; however, pregnancy rates are low in herds presenting high anestrous rates and moderate to low body condition. The addition of an eCG treatment at the time of device removal, which increased plasma progesterone concentrations and pregnancy rates in anestrous postpartum suckled B. indicus cows, may be useful to improve reproductive performance of beef cattle in tropical climates.
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              Risk factors for resumption of postpartum estrous cycles and embryonic survival in lactating dairy cows.

              The objectives of this study were to evaluate factors associated with resumption of postpartum estrous cycles and embryonic survival in lactating dairy cows. Holstein cows, 6396 from four dairy farms were evaluated to determine the relationships among parity, body condition score (BCS) at calving and at AI, season of year when cows calved, and milk yield on resumption of postpartum estrous cycles by 65 days postpartum, and all the previous variables, estrual or anestrus and AI protocol on conception rates and embryonic survival at the first postpartum insemination. Cows had their estrous cycle pre-synchronized with two PGF(2alpha) injections given 14 days apart and were inseminated between 69 and 82 days postpartum following either an estrous or ovulation synchronization protocol initiated 12-14 days after the presynchronization. Blood was sampled and analyzed for progesterone twice, 12-14 days apart, to determine whether cows had initiated onset of estrous cycles after calving. Cows were scored for body condition in the week after calving, and again at AI, between 69 and 82 days postpartum. Pregnancy was diagnosed at 30+/-3 and 58+/-3 days after AI. Farm influenced all reproductive outcomes evaluated. More (P<0.0001) multiparous than primiparous cows had initiated estrous cycles. Onset of estrous cycles was also influenced (P<0.01) by BCS at calving and at AI, BCS change, season, and milk yield. More (P<0.001) cows that had initiated estrous cycles than anestrous cows were pregnant at 30 and 58 days after AI, but anestrus did not affect pregnancy loss. Conception rates were also influenced (P<0.01) by parity, BCS at calving and AI, BCS change, and season; however, milk yield and insemination protocol were not associated with conception rates at 30 and 58 days after AI. Factors that reduced conception rate on day 30 after AI also increased pregnancy loss between 30 and 58 days of gestation. Improving BCS at calving and AI, minimizing losses of BCS after calving, and hastening onset of estrous cycles early postpartum are all expected to increase conception because of enhanced embryonic survival.
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                Author and article information

                Journal
                Reproduction, Fertility and Development
                Reprod. Fertil. Dev.
                CSIRO Publishing
                1031-3613
                2012
                2012
                : 24
                : 1
                : 258
                Article
                10.1071/RD11916
                1adc16da-7396-4bfe-873b-3c7688ffe7a5
                © 2012
                History

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