There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Human adipose tissue expresses and releases the proinflammatory cytokine interleukin
6, potentially inducing low-grade systemic inflammation in persons with excess body
fat.
To test whether overweight and obesity are associated with low-grade systemic inflammation
as measured by serum C-reactive protein (CRP) level.
The Third National Health and Nutrition Examination Survey, representative of the
US population from 1988 to 1994.
A total of 16616 men and nonpregnant women aged 17 years or older.
Elevated CRP level of 0.22 mg/dL or more and a more stringent clinically raised CRP
level of more than 1.00 mg/dL.
Elevated CRP levels and clinically raised CRP levels were present in 27.6% and 6.7%
of the population, respectively. Both overweight (body mass index [BMI], 25-29.9 kg/m2)
and obese (BMI, > or =30 kg/m2) persons were more likely to have elevated CRP levels
than their normal-weight counterparts (BMI, <25 kg/m2). After adjustment for potential
confounders, including smoking and health status, the odds ratio (OR) for elevated
CRP was 2.13 (95% confidence interval [CI], 1.56-2.91) for obese men and 6.21 (95%
CI, 4.94-7.81) for obese women. In addition, BMI was associated with clinically raised
CRP levels in women, with an OR of 4.76 (95% CI, 3.42-6.61) for obese women. Waist-to-hip
ratio was positively associated with both elevated and clinically raised CRP levels,
independent of BMI. Restricting the analyses to young adults (aged 17-39 years) and
excluding smokers, persons with inflammatory disease, cardiovascular disease, or diabetes
mellitus and estrogen users did not change the main findings.
Higher BMI is associated with higher CRP concentrations, even among young adults aged
17 to 39 years. These findings suggest a state of low-grade systemic inflammation
in overweight and obese persons.