For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
59
references
 Top references
cited by
3
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      144
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes

      Preprint
      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus. TDP-43 loss leads to cryptic exon inclusion but a role in other RNA processing events remains unresolved. Here, we show that loss of TDP-43 causes widespread changes in alternative polyadenylation, impacting expression of disease-relevant genes (e.g., ELP1, NEFL, and TMEM106B) and providing evidence that alternative polyadenylation is a new facet of TDP-43 pathology.

          Related collections

          Most cited references59

          • Record: found
          • Abstract: found
          • Article: not found

          Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis.

          Shuo-Chien Ling, Magdalini Polymenidou, Don Cleveland (2013)
          Breakthrough discoveries identifying common genetic causes for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these disorders. They share unexpectedly similar signatures, including dysregulation in common molecular players including TDP-43, FUS/TLS, ubiquilin-2, VCP, and expanded hexanucleotide repeats within the C9ORF72 gene. Dysfunction in RNA processing and protein homeostasis is an emerging theme. We present the case here that these two processes are intimately linked, with disease-initiated perturbation of either leading to further deviation of both protein and RNA homeostasis through a feedforward loop including cell-to-cell prion-like spread that may represent the mechanism for relentless disease progression. Copyright © 2013 Elsevier Inc. All rights reserved.
          Article 0 comments Cited 395 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found

            Neurofilament light chain as a biomarker in neurological disorders

            Lorenzo Gaetani, Kaj Blennow, Paolo Calabresi … (2019)
            In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases. New immunoassays able to detect biomarkers at ultralow levels have allowed for the measurement of NfL in blood, thus making it possible to easily and repeatedly measure NfL for monitoring diseases’ courses. Evidence that both CSF and blood NfL may serve as diagnostic, prognostic and monitoring biomarkers in neurological diseases is progressively increasing, and NfL is one of the most promising biomarkers to be used in clinical and research setting in the next future. Here we review the most important results on CSF and blood NfL and we discuss its potential applications and future directions.
            Article 0 comments Cited 394 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Alternative polyadenylation of mRNA precursors

              Jin-bin Tian, James Manley (2016)
              Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for
              Article 0 comments Cited 329 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): bioRxiv
                Journal ID (publisher-id): BIORXIV
                Title: bioRxiv
                Publisher: Cold Spring Harbor Laboratory
                Publication date (Electronic): 22 January 2024
                Electronic Location Identifier: 2024.01.22.575730
                Affiliations
                [1 ]Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
                [2 ]Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
                [3 ]Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA
                [4 ]Chan Zuckerberg Biohub – San Francisco, San Francisco, CA, USA
                Author notes
                [5 ] Correspondence: agitler@ 123456stanford.edu
                Author information
                http://orcid.org/0000-0001-7189-7917
                http://orcid.org/0000-0001-8603-1526
                Article
                DOI: 10.1101/2024.01.22.575730
                PMC ID: 10849503
                PubMed ID: 38328059
                SO-VID: 1953dc1b-39f3-4977-952d-ee5f5cd764cc
                License:

                This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.

                History
                Categories
                Subject: Article

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content144

                See all similar

                Cited by3

                See all cited by

                Most referenced authors1,045

                See all reference authors