For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
18
views
113
references
 Top references
cited by
87
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      396
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

      review-article
      Author(s): 1 , 1 , 2 , *
      Publication date (Electronic):
      Journal: Microorganisms
      Publisher: MDPI
      Keywords: quorum sensing, microbial resistance, biofilm, quorum quenching

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome and is related to cell density. The high-density colony population can generate a sufficient number of small molecule signals, activate a variety of downstream cellular processes including virulence and drug resistance mechanisms, tolerate antibiotics, and harm the host. This article gives a general introduction to the current research status of microbial quorum-sensing systems, focuses on the role of quorum-sensing systems in regulating microbial resistance mechanisms, such as drug efflux pump and microbial biofilm formation regulation, and discusses a new strategy for the treatment of drug-resistant bacteria proposed by using quorum quenching to prevent microbial resistance.

          Related collections

          Most cited references113

          • Record: found
          • Abstract: found
          • Article: not found

          Antibiotic resistance-the need for global solutions.

          Ramanan Laxminarayan, Adriano Duse, Chand Wattal … (2013)
          The causes of antibiotic resistance are complex and include human behaviour at many levels of society; the consequences affect everybody in the world. Similarities with climate change are evident. Many efforts have been made to describe the many different facets of antibiotic resistance and the interventions needed to meet the challenge. However, coordinated action is largely absent, especially at the political level, both nationally and internationally. Antibiotics paved the way for unprecedented medical and societal developments, and are today indispensible in all health systems. Achievements in modern medicine, such as major surgery, organ transplantation, treatment of preterm babies, and cancer chemotherapy, which we today take for granted, would not be possible without access to effective treatment for bacterial infections. Within just a few years, we might be faced with dire setbacks, medically, socially, and economically, unless real and unprecedented global coordinated actions are immediately taken. Here, we describe the global situation of antibiotic resistance, its major causes and consequences, and identify key areas in which action is urgently needed. Copyright © 2013 Elsevier Ltd. All rights reserved.
          Article 0 comments Cited 1399 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Progress in and promise of bacterial quorum sensing research

            E. Peter Greenberg, Stephen P. Diggle, Marvin Whiteley (2017)
            This Review highlights how we can build upon the relatively new and rapidly developing field of research into bacterial quorum sensing (QS). We now have a depth of knowledge about how bacteria use QS signals to communicate with each other and to coordinate their activities.
            Article 0 comments Cited 362 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Structural identification of a bacterial quorum-sensing signal containing boron.

              Xin CHEN, Stephan Schauder, Noëlle Potier … (2002)
              Cell-cell communication in bacteria is accomplished through the exchange of extracellular signalling molecules called autoinducers. This process, termed quorum sensing, allows bacterial populations to coordinate gene expression. Community cooperation probably enhances the effectiveness of processes such as bioluminescence, virulence factor expression, antibiotic production and biofilm development. Unlike other autoinducers, which are specific to a particular species of bacteria, a recently discovered autoinducer (AI-2) is produced by a large number of bacterial species. AI-2 has been proposed to serve as a 'universal' signal for inter-species communication. The chemical identity of AI-2 has, however, proved elusive. Here we present the crystal structure of an AI-2 sensor protein, LuxP, in a complex with autoinducer. The bound ligand is a furanosyl borate diester that bears no resemblance to previously characterized autoinducers. Our findings suggest that addition of naturally occurring borate to an AI-2 precursor generates active AI-2. Furthermore, they indicate a potential biological role for boron, an element required by a number of organisms but for unknown reasons.
              Article 0 comments Cited 299 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Microorganisms
                Journal ID (iso-abbrev): Microorganisms
                Journal ID (publisher-id): microorganisms
                Title: Microorganisms
                Publisher: MDPI
                ISSN (Electronic): 2076-2607
                Publication date (Electronic): 17 March 2020
                Publication date Collection: March 2020
                Volume: 8
                Issue: 3
                Electronic Location Identifier: 425
                Affiliations
                [1 ]Research Center for Environmental Ecology and Engineering, Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemistry Technology, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan 430205, China; xhzhao2006@ 123456gmail.com (X.Z.); zixuanyu1996@ 123456163.com (Z.Y.)
                [2 ]College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China
                Author notes
                [* ]Correspondence: tding@ 123456zju.edu.cn
                Author information
                https://orcid.org/0000-0003-1491-7808
                Article
                Publisher ID: microorganisms-08-00425
                DOI: 10.3390/microorganisms8030425
                PMC ID: 7143945
                PubMed ID: 32192182
                SO-VID: 134cca2f-4cfa-4bf9-be46-0cf0348617c1
                Copyright © © 2020 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 01 March 2020
                Date accepted : 16 March 2020
                Categories
                Subject: Review

                Keywords: quorum sensing,microbial resistance,biofilm,quorum quenching
                Data availability:
                Keywords: quorum sensing, microbial resistance, biofilm, quorum quenching

                Comments

                Comment on this article

                scite_

                Similar content396

                See all similar

                Cited by86

                See all cited by

                Most referenced authors2,114

                See all reference authors