Circadian and Circannual Rhythms in Thyroid Hormones: Determining the TSH and Free T4 Reference Intervals Based Upon Time of Day, Age, and Sex.

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Abstract

Establishing the reference interval for thyrotropin (TSH) and free thyroxine (T4) is clinically important because a number of disease states have been linked to alterations in TSH and free T4 concentrations that are within the 95% confidence interval for normal thyroid hormone values. Age, sex, time of day, and ethnicity are known to affect circulating levels of TSH and free T4 but have not been used to establish reference intervals. The purpose of this study was to define the reference interval for TSH and free T4 taking into account age, sex, ethnicity, and circadian and circannual variability.

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Journal

Journal ID (iso-abbrev): Thyroid

Title: Thyroid : official journal of the American Thyroid Association

ISSN (Electronic): 1557-9077

ISSN (Print): 1050-7256

Publication date (Electronic): Aug 2015

Volume: 25

Issue: 8

Affiliations

[1 ] 1 Department of Medicine, Intermountain Central Laboratory , Murray, Utah.

[2 ] 2 Central Laboratory, Intermountain Healthcare , Murray, Utah.

[3 ] 3 Statistical Data Center, Intermountain Healthcare Research , Salt Lake City, Utah.

[4 ] 4 Department of Medicine, McKee-Dee Hospital , Ogden, Utah.

[5 ] 5 Intermountain Healthcare , Salt Lake City, Utah.

[6 ] 6 Department of Clinical and Experimental Medicine, Policlinico Universitario di Messina , Messina, Italy .

Article

DOI: 10.1089/thy.2014.0589

PubMed ID: 26061389

SO-VID: 0912c316-f518-42f8-ae86-5bb16e5bde21

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