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      New insights into perinatal testicular torsion

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          Abstract

          Perinatal testicular torsion is a relatively rare event that remains unrecognized in many patients or is suspected and treated accordingly only after an avoidable loss of time. The authors report their own experience with several patients, some of them quite atypical but instructive. Missed bilateral torsion is an issue, as are partial torsion, possible antenatal signs, and late presentation. These data are discussed together with the existing literature and may help shed new light on the natural course of testicular torsion and its treatment. The most important conclusion is that a much higher index of suspicion based on clinical findings is needed for timely detection of perinatal torsion. It is the authors’ opinion that immediate surgery is mandatory not only in suspected bilateral torsions but also in cases of possible unilateral torsions. There is no place for a more fatalistic “wait-and-see” approach. Whenever possible, even necrotic testes should not be removed during surgery because some endocrine function may be retained.

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          Most cited references46

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          Fetal pain: a systematic multidisciplinary review of the evidence.

          Proposed federal legislation would require physicians to inform women seeking abortions at 20 or more weeks after fertilization that the fetus feels pain and to offer anesthesia administered directly to the fetus. This article examines whether a fetus feels pain and if so, whether safe and effective techniques exist for providing direct fetal anesthesia or analgesia in the context of therapeutic procedures or abortion. Systematic search of PubMed for English-language articles focusing on human studies related to fetal pain, anesthesia, and analgesia. Included articles studied fetuses of less than 30 weeks' gestational age or specifically addressed fetal pain perception or nociception. Articles were reviewed for additional references. The search was performed without date limitations and was current as of June 6, 2005. Pain perception requires conscious recognition or awareness of a noxious stimulus. Neither withdrawal reflexes nor hormonal stress responses to invasive procedures prove the existence of fetal pain, because they can be elicited by nonpainful stimuli and occur without conscious cortical processing. Fetal awareness of noxious stimuli requires functional thalamocortical connections. Thalamocortical fibers begin appearing between 23 to 30 weeks' gestational age, while electroencephalography suggests the capacity for functional pain perception in preterm neonates probably does not exist before 29 or 30 weeks. For fetal surgery, women may receive general anesthesia and/or analgesics intended for placental transfer, and parenteral opioids may be administered to the fetus under direct or sonographic visualization. In these circumstances, administration of anesthesia and analgesia serves purposes unrelated to reduction of fetal pain, including inhibition of fetal movement, prevention of fetal hormonal stress responses, and induction of uterine atony. Evidence regarding the capacity for fetal pain is limited but indicates that fetal perception of pain is unlikely before the third trimester. Little or no evidence addresses the effectiveness of direct fetal anesthetic or analgesic techniques. Similarly, limited or no data exist on the safety of such techniques for pregnant women in the context of abortion. Anesthetic techniques currently used during fetal surgery are not directly applicable to abortion procedures.
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            Testicular torsion: late results with special regard to fertility and endocrine function.

            Late results were determined for 42 patients who had undergone detorsion and fixation for unilateral testicular torsion in the prepubertal and pubertal age. Exocrine and endocrine function for the testes was determined in 30 patients who had reached postpuberal age. Patients who underwent detorsion and fixation 8 hours or less after the onset of symptoms had normal-sized testicles and only slight changes in testicular morphology. When treatment was delayed and detorsion was done more than 8 hours later a marked decrease was observed in testicular size. The exocrine function in patients with torsion was reduced. The semen quality, as judged by 2 semen analyses, was normal in 15 patients, doubtful in 3 and pathological in 12. Even when detorsion was done 4 hours or less after the onset of symptoms the exocrine function of the testes was normal in only 50 per cent of the cases. In patients with doubtful and pathological sperm analyses higher follicle-stimulating and luteinizing hormone levels were observed.
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              The remnant orchiectomy.

              We examined and characterized the histological features of remnant testicular tissue distal to the internal inguinal ring in boys who underwent exploration for a nonpalpable testis. The medical records and histology of 48 boys (50 remnants) who underwent exploration for a nonpalpable testis during a 10-year period were reviewed in detail. Remnant tissue was characterized by evidence of ischemia and necrosis (scar, calcification, hemosiderin and hyalinization) suggestive of a vascular accident. Viable germ cells were identified in 5 remnants. A 10% incidence of viable germ cells in remnant testicular tissue warrants exploration and removal of all remnant tissue in boys who undergo exploration for a nonpalpable testis.
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                Author and article information

                Contributors
                +31-43-3877258 , +31-43-3875259 , Piet.Callewaert@mumc.nl
                Journal
                Eur J Pediatr
                European Journal of Pediatrics
                Springer-Verlag (Berlin/Heidelberg )
                0340-6199
                1432-1076
                25 October 2009
                25 October 2009
                June 2010
                : 169
                : 6
                : 705-712
                Affiliations
                Department of Urology, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands
                Article
                1096
                10.1007/s00431-009-1096-8
                2859224
                19856186
                ac72722b-21f0-442c-a72e-b3e38ff1f37e
                © The Author(s) 2009
                History
                : 15 July 2009
                : 12 October 2009
                Categories
                Original Paper
                Custom metadata
                © Springer-Verlag 2010

                Pediatrics
                perinatal testicular torsion,extravaginal torsion of testis,bilateral spermatic cord torsion

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