G – ScienceOpen
6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Book Chapter: not found
      Dictionary of Drugs 

      G

      other
      ,
      Springer US

      Read this book at

      Buy book Bookmark
          There is no author summary for this book yet. Authors can add summaries to their books on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references212

          • Record: found
          • Abstract: not found
          • Article: not found

          GENTAMICIN, A NEW ANTIBIOTIC COMPLEX FROM MICROMONOSPORA.

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Gossypol, a pigment of cottonseed.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Neutral sites for calcium ion binding to elastin and collagen: a charge neutralization theory for calcification and its relationship to atherosclerosis.

              D. W. Urry (1971)
              Neutral, uncharged binding sites for calcium ions are proposed for elastin and collagen. The sites utilize, particularly from a conformational viewpoint, the most striking feature of the amino acid composition, that is, the high glycine content. Glycines favor the formation of beta-turns and associated conformations that are known, from studies on ion-transporting antibiotics, to interact with cations. By analogy with certain antibiotics, which are uncharged polypeptides and depsipeptides that bind cations by coordination with neutral acyl oxygens, it is proposed that calcium-ion binding also utilizes uncharged coordinating groups, i.e., neutral sites, in the protein matrix. The protein matrix, which becomes positively charged by virtue of the bound calcium ions, attracts neutralizing phosphate and carbonate ions, which then allow further calcium ion binding. The driving force is, therefore, the affinity of calcium ions for the neutral nucleation sites. The charge neutralization theory of calcification suggests a fundamental role of organic anions, for example sulfated mucopolysaccharides, in regulating bone formation and in retardation of atherosclerosis. The proposed mechanism contains elements that tend to unify several theories on the pathogenesis of atherosclerosis.
                Bookmark

                Author and book information

                Book Chapter
                1990
                : 590-616
                10.1007/978-1-4757-2085-3_7
                85f4195f-4b5c-4140-91c9-fb59c7dc43ab
                History

                Comments

                Comment on this book

                Book chapters

                Similar content400