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Abstract

We cloned the C. elegans gene ced-1, which is required for the engulfment of cells undergoing programmed cell death. ced-1 encodes a transmembrane protein similar to human SREC (Scavenger Receptor from Endothelial Cells). We showed that ced-1 is expressed in and functions in engulfing cells. The CED-1 protein localizes to cell membranes and clusters around neighboring cell corpses. CED-1 failed to cluster around cell corpses in mutants defective in the engulfment gene ced-7. Motifs in the intracellular domain of CED-1 known to interact with PTB and SH2 domains were necessary for engulfment but not for clustering. Our results indicate that CED-1 is a cell surface phagocytic receptor that recognizes cell corpses. We suggest that the ABC transporter CED-7 promotes cell corpse recognition by CED-1, possibly by exposing a phospholipid ligand on the surfaces of cell corpses.

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PubMed ID:: 11163239

DOI:: 10.1016/S0092-8674(01)00190-8

ScienceOpen disciplines: Chemistry

Keywords: ATP-Binding Cassette Transporters,genetics,Alleles,Animals,Animals, Genetically Modified,Apoptosis,physiology,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Cloning, Molecular,Consensus Sequence,Epidermal Growth Factor,Membrane Proteins,metabolism,Molecular Sequence Data,Mutation,Phagocytosis,Phenotype,Protein Binding,Receptors, Immunologic,Receptors, Lipoprotein,Receptors, Scavenger,Repetitive Sequences, Nucleic Acid,Scavenger Receptors, Class B,Sequence Homology, Amino Acid,Signal Transduction,Transgenes,src Homology Domains

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