Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance.

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Abstract

Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) was recently identified as a protein that is released from mitochondria in response to apoptotic stimuli and promotes apoptosis by antagonizing inhibitor of apoptosis proteins. Furthermore, Smac/DIABLO plays an important regulatory role in the sensitization of cancer cells to both immune- and drug-induced apoptosis. However, little is known about the clinical significance of Smac/DIABLO in various cancers, including renal cell carcinoma (RCC). This study examined Smac/DIABLO expression in 78 healthy kidneys and 78 RCCs.

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Journal

Journal ID (iso-abbrev): J Clin Oncol

Title: Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Publisher: American Society of Clinical Oncology (ASCO)

ISSN: 0732-183X

ISSN (Print): 0732-183X

Publication date (Electronic): Jan 20 2005

Volume: 23

Issue: 3

Affiliations

[1 ] Department of Urology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. ymizutan@koto.kpu-m.ac.jp

Article

Publisher Item ID: JCO.2005.02.191

DOI: 10.1200/JCO.2005.02.191

PubMed ID: 15572731

SO-VID: e2357531-a8b4-4a0e-98fc-522a7e39cfc1

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