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The genetics of adiponectin.

Author(s): Francis Vasseur, Frédéric Leprêtre, Philippe Froguel, C Lacquemant

Publication date: 2003-03-31

Keywords: Adiponectin, Animals, Arteriosclerosis, genetics, Coronary Disease, Diabetes Mellitus, Type 2, Exons, Gene Deletion, Genetic Variation, Humans, Insulin Resistance, Intercellular Signaling Peptides and Proteins, Introns, Metabolic Syndrome X, Point Mutation, Proteins

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Abstract

Adiponectin encoded by the APMI gene is one of the adipocyte-expressed proteins that function in the homeostatic control of glucose, lipid, and energy metabolism. Its dysregulation has been suggested to be involved in disorders covering the metabolic X syndrome, such as insulin resistance, obesity, type 2 diabetes, and coronary artery disease. Recent data present evidence of a genetic modulation of the adiponectin level, and linkage of the 3q27 locus, where the APMI gene lies, with diabetes and features of the metabolic X syndrome playing a putative role of the APMI gene in this syndrome. In this article, we present an overview of the results available to date and discuss positive evidence for a role of genetic variants of the APMI gene and questions that genetic data raise.

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PubMed ID:: 12728641

DOI:: 10.1007/s11892-003-0039-4

ScienceOpen disciplines: Chemistry

Keywords: Adiponectin,Animals,Arteriosclerosis,genetics,Coronary Disease,Diabetes Mellitus, Type 2,Exons,Gene Deletion,Genetic Variation,Humans,Insulin Resistance,Intercellular Signaling Peptides and Proteins,Introns,Metabolic Syndrome X,Point Mutation,Proteins

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ScienceOpen disciplines: Chemistry

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