Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

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Abstract

Three novel nonoclonal antibodies (designed OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cel- lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocyted in that they did not react with normal B cells, null cells, monocytes, or granulocytes.

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Journal

Title: Science

Abbreviated Title: Science

Publisher: American Association for the Advancement of Science (AAAS)

ISSN (Print): 0036-8075

ISSN (Electronic): 1095-9203

Publication date Created: October 19 1979

Publication date (Print): October 19 1979

Volume: 206

Issue: 4416

Pages: 347-349

Affiliations

[1 ]Ortho Pharmaceutical Corporation, Raritan, New Jersey 08869

[2 ]Division of Tumor Immunology, Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115

Article

DOI: 10.1126/science.314668

PubMed ID: 314668

SO-VID: c44464af-0a73-463e-b4cf-9793d25c97a2

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