Immunobiology of the TAM receptors.

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Abstract

Recent studies have revealed that the TAM receptor protein tyrosine kinases--TYRO3, AXL and MER--have pivotal roles in innate immunity. They inhibit inflammation in dendritic cells and macrophages, promote the phagocytosis of apoptotic cells and membranous organelles, and stimulate the maturation of natural killer cells. Each of these phenomena may depend on a cooperative interaction between TAM receptor and cytokine receptor signalling systems. Although its importance was previously unrecognized, TAM signalling promises to have an increasingly prominent role in studies of innate immune regulation.

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Journal

Journal ID (iso-abbrev): Nat Rev Immunol

Title: Nature reviews. Immunology

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1474-1741

ISSN (Print): 1474-1733

Publication date (Electronic): May 2008

Volume: 8

Issue: 5

Affiliations

[1 ] Molecular Neurobiology Laboratory, The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA. lemke@salk.edu

Article

Publisher Item ID: nri2303 Mid ID: NIHMS186783

DOI: 10.1038/nri2303

PMC ID: 2856445

PubMed ID: 18421305

SO-VID: 80edbccd-c154-4f04-9a36-d0d640261bcf

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