Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages.

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Abstract

Previous studies demonstrated that obese adipose tissue is characterized by increased infiltration of macrophages, suggesting that they might represent an important source of inflammation. Using an in vitro coculture system composed of 3T3-L1 adipocytes and RAW264 macrophages, we previously demonstrated that saturated fatty acids (FAs) and tumor necrosis factor (TNF)-alpha derived from adipocytes and macrophages, respectively, play a major role in the coculture-induced inflammatory changes.

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Journal

Journal ID (iso-abbrev): Arterioscler Thromb Vasc Biol

Title: Arteriosclerosis, thrombosis, and vascular biology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4636

ISSN (Print): 1079-5642

Publication date (Electronic): Jan 2007

Volume: 27

Issue: 1

Affiliations

[1 ] Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.

Article

Publisher Item ID: 01.ATV.0000251608.09329.9a

DOI: 10.1161/01.ATV.0000251608.09329.9a

PubMed ID: 17082484

SO-VID: 7f9c10c6-699b-47a4-9d46-b8e5e2c05700

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