Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes.

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Abstract

Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+)-permeable channel that can be gated by tonicity (osmolarity) and mechanical stimuli. Chondrocytes, the cells in cartilage, respond to their osmotic and mechanical environments; however, the molecular basis of this signal transduction is not fully understood. This study was undertaken to demonstrate the presence and functionality of TRPV4 in chondrocytes.

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Journal

Journal ID (iso-abbrev): Arthritis Rheum

Title: Arthritis and rheumatism

Publisher: Wiley

ISSN: 0004-3591

ISSN (Print): 0004-3591

Publication date (Electronic): Oct 2009

Volume: 60

Issue: 10

Affiliations

[1 ] Duke University Medical Center, Durham, North Carolina 27710, USA.

Article

Mid ID: NIHMS178456

DOI: 10.1002/art.24799

PMC ID: 2846816

PubMed ID: 19790068

SO-VID: 540971e3-1f5e-40b5-a8fa-e324a0c7cd9f

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