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Abstract

A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.

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PubMed ID:: 6783959

DOI:: 10.1038/290372a0

ScienceOpen disciplines: Chemistry

Keywords: Alleles,Animals,B-Lymphocytes,immunology,Chromosome Deletion,Gene Expression Regulation,Immunoglobulin Fragments,genetics,Immunoglobulin Heavy Chains,Immunoglobulin kappa-Chains,Immunoglobulin lambda-Chains,Immunoglobulins,Leukemia, Experimental,Mice,Plasmacytoma,Recombination, Genetic

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ScienceOpen disciplines: Chemistry

Keywords: Alleles, Animals, B-Lymphocytes, immunology, Chromosome Deletion, Gene Expression Regulation, Immunoglobulin Fragments, genetics, Immunoglobulin Heavy Chains, Immunoglobulin kappa-Chains, Immunoglobulin lambda-Chains, Immunoglobulins, Leukemia, Experimental, Mice, Plasmacytoma, Recombination, Genetic

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