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      Protein S-glutathionylation: a regulatory device from bacteria to humans

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      Trends in Biochemical Sciences
      Elsevier BV

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          Abstract

          S-Glutathionylation is the specific post-translational modification of protein cysteine residues by the addition of the tripeptide glutathione, the most abundant and important low-molecular-mass thiol within most cell types. Protein S-glutathionylation is promoted by oxidative or nitrosative stress but also occurs in unstressed cells. It can serve to regulate a variety of cellular processes by modulating protein function and to prevent irreversible oxidation of protein thiols. Recent findings support an essential role for S-glutathionylation in the control of cell-signalling pathways associated with viral infections and with tumour necrosis factor-(-induced apoptosis. Glyceraldehyde-3-phosphate dehydrogenase has recently been implicated in the regulation of endothelin-1 synthesis by a novel, S-glutathionylation-based mechanism involving messenger RNA stability. Moreover, recent studies have identified S-glutathionylation as a redox signalling mechanism in plants.

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          Author and article information

          Journal
          Trends in Biochemical Sciences
          Trends in Biochemical Sciences
          Elsevier BV
          09680004
          February 2009
          February 2009
          : 34
          : 2
          : 85-96
          Article
          10.1016/j.tibs.2008.11.002
          19135374
          51534fb0-9aa5-430b-a0f3-9390bfa765c6
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

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