A new copper acetate-bis(oxazoline)-catalyzed, enantioselective Henry reaction.

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Abstract

A highly enantioselective, nitroaldol reaction catalyzed by a chiral Cu(II) bis(oxazoline) complex has been developed. The reaction scope includes both aromatic and aliphatic aldehydes (15 examples) affording products in good yields and enantioselectivities (87-94% ee). An X-ray structure of the catalyst has been provided along with a rationalization of the sense of asymmetric induction.

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Journal

Journal ID (iso-abbrev): J. Am. Chem. Soc.

Title: Journal of the American Chemical Society

ISSN: 0002-7863

ISSN (Print): 0002-7863

Publication date (Electronic): Oct 22 2003

Volume: 125

Issue: 42

Affiliations

[1 ] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA. evans@chemistry.harvard.edu

Article

DOI: 10.1021/ja0373871

PubMed ID: 14558801

SO-VID: 22d08e05-3289-40a2-93f0-e90b4483c018

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