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hBD-1: a novel beta-defensin from human plasma.

Author(s): K. Bensch, W. Forssmann, H Mägert, M Raida, Vincent Schulz

Publication date: 1995-07-17

Keywords: Amino Acid Sequence, Amino Acids, analysis, Animals, Base Sequence, Blood, Blood Proteins, chemistry, genetics, isolation & purification, Cattle, Chickens, Cloning, Molecular, DNA, Complementary, Defensins, Female, Hemofiltration, Humans, Kidney, Molecular Sequence Data, Molecular Weight, Sequence Analysis, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Vagina, beta-Defensins

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Abstract

We report the isolation and characterization of a novel peptide with significant sequence homology to beta-defensins from human blood filtrate. The human beta-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD-1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide. hBD-1 shares the nine conserved amino acids characteristic for beta-defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD-1 is present in nanomolar concentration in human plasma.