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Abstract

Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a substrate of the c-Abl tyrosine kinase. Active c-Abl kinase leads to Cdk5 tyrosine phosphorylation, and this phosphorylation is enhanced by Cables. Phosphorylation of Cdk5 by c-Abl occurs on tyrosine 15 (Y15), which is stimulatory for p35/Cdk5 kinase activity. Expression of antisense Cables in primary cortical neurons inhibited neurite outgrowth. Furthermore, expression of active Abl resulted in lengthening of neurites. The data provide evidence for a Cables-mediated interplay between the Cdk5 and c-Abl signaling pathways in the developing nervous system.

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PubMed ID:: 10896159

DOI:: 10.1016/s0896-6273(00)81200-3

ScienceOpen disciplines: Chemistry

Keywords: Amino Acid Sequence,genetics,Animals,Base Sequence,COS Cells,Carrier Proteins,metabolism,physiology,Cells, Cultured,Cyclin-Dependent Kinase 5,Cyclin-Dependent Kinases,Cyclins,Embryo, Mammalian,Mice,Mitosis,Molecular Sequence Data,Neurites,Neurons,Phosphoproteins,Phosphorylation,Phosphotransferases,Proto-Oncogene Proteins c-abl,Substrate Specificity,Tyrosine,Up-Regulation

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ScienceOpen disciplines: Chemistry

Keywords: Amino Acid Sequence, genetics, Animals, Base Sequence, COS Cells, Carrier Proteins, metabolism, physiology, Cells, Cultured, Cyclin-Dependent Kinase 5, Cyclin-Dependent Kinases, Cyclins, Embryo, Mammalian, Mice, Mitosis, Molecular Sequence Data, Neurites, Neurons, Phosphoproteins, Phosphorylation, Phosphotransferases, Proto-Oncogene Proteins c-abl, Substrate Specificity, Tyrosine, Up-Regulation

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