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      Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

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          Abstract

          Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed to assess the effects of monoclonal antibody to IL-5 on blood and sputum eosinophils, airway hyper-responsiveness, and the late asthmatic reaction to inhaled allergen in patients with mild asthma.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          0140-6736
          0140-6736
          February 24 2001
          : 356
          : 9248
          Affiliations
          [1 ] National Heart and Lung Institute, Imperial College, London, UK.
          Article
          S0140673600034966
          10.1016/s0140-6736(00)03496-6
          11191542
          d83e9fa2-0440-4bfd-a57f-4fa452e72c5e
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