The Cbl interactome and its functions.

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Abstract

Cbl proteins are ubiquitin ligases and multifunctional adaptor proteins that are implicated in the regulation of signal transduction in various cell types and in response to different stimuli. Cbl-associated proteins can assemble together at a given time or space inside the cell, and such an interactome can form signal competent networks that control many physiological processes. Dysregulation of spatial or temporal constraints in the Cbl interactome results in the development of human pathologies such as immune diseases, diabetes and cancer.

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Journal

Journal ID (iso-abbrev): Nat Rev Mol Cell Biol

Title: Nature reviews. Molecular cell biology

Publisher: Springer Science and Business Media LLC

ISSN: 1471-0072

ISSN (Print): 1471-0072

Publication date (Electronic): December 2005

Volume: 6

Issue: 12

Affiliations

[1 ] Institute for Biochemistry II, Goethe University Medical School, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

Article

Publisher Item ID: nrm1762

DOI: 10.1038/nrm1762

PubMed ID: 16227975

SO-VID: cf572856-a82e-4a86-b7e1-114f971a7e8c

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