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Abstract

The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking.

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PubMed ID:: 10209735

DOI:: 10.1046/j.1365-2958.1999.01279.x

ScienceOpen disciplines: Chemistry

Keywords: Carrier Proteins,physiology,Cation Transport Proteins,Cells, Cultured,Cytokines,GTP-Binding Proteins,metabolism,Membrane Proteins,Microscopy, Confocal,Models, Biological,Mycobacterium bovis,Mycobacterium tuberculosis,Phagocytosis,Phagosomes,rab GTP-Binding Proteins,rab5 GTP-Binding Proteins

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ScienceOpen disciplines: Chemistry

Keywords: Carrier Proteins, physiology, Cation Transport Proteins, Cells, Cultured, Cytokines, GTP-Binding Proteins, metabolism, Membrane Proteins, Microscopy, Confocal, Models, Biological, Mycobacterium bovis, Mycobacterium tuberculosis, Phagocytosis, Phagosomes, rab GTP-Binding Proteins, rab5 GTP-Binding Proteins

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