Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure.

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Abstract

Despite widely reported clinical and preclinical studies of rapid antidepressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists, there has been very little work examining the effects of these drugs in stress models of depression that require chronic administration of antidepressants or the molecular mechanisms that could account for the rapid responses.

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Journal

Journal ID (iso-abbrev): Biol Psychiatry

Title: Biological psychiatry

Publisher: Elsevier BV

ISSN (Electronic): 1873-2402

ISSN (Print): 0006-3223

Publication date (Electronic): Apr 15 2011

Volume: 69

Issue: 8

Affiliations

[1 ] Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA.

Article

Mid ID: NIHMS272590 Publisher Item ID: S0006-3223(10)01306-5

DOI: 10.1016/j.biopsych.2010.12.015

PMC ID: 3068225

PubMed ID: 21292242

SO-VID: a993f0bc-1a3b-4a08-9426-870a21f6d436

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