Advanced protein glycosylation in diabetes and aging.

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Abstract

Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins. Pharmacologic inhibition of AGE formation in long-term diabetic animals prevents diabetic retinopathy, nephropathy, neuropathy, and arterial abnormalities in animal models. Clinical trials in humans are currently in progress.

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Journal

Journal ID (iso-abbrev): Annu Rev Med

Title: Annual review of medicine

Publisher: Annual Reviews

ISSN: 0066-4219

ISSN (Print): 0066-4219

Publication date (Electronic): 1995

Volume: 46

Affiliations

[1 ] Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Article

DOI: 10.1146/annurev.med.46.1.223

PubMed ID: 7598459

SO-VID: a40c2874-970e-401d-bc48-22e5967fb1ec

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