Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture.

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Abstract

Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.

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Journal

Journal ID (iso-abbrev): Nat Genet

Title: Nature genetics

Publisher: Springer Science and Business Media LLC

ISSN: 1061-4036

ISSN (Print): 1061-4036

Publication date (Electronic): Feb 2001

Volume: 27

Issue: 2

Affiliations

[1 ] Roslin Institute (Edinburgh), Roslin, Midlothian, Scotland, UK. Lorraine.Young@bbsrc.ac.uk

Article

DOI: 10.1038/84769

PubMed ID: 11175780

SO-VID: 9ba74dcc-2d6e-482d-a3f1-50b134d87fd5

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