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Abstract

Prostate cancer, while initially dependent on androgens for proliferation, progresses to an androgen-independent state. Evidence has been accumulating that interleukin-6 (IL-6) may contribute to prostate cancer progression. Serum levels of IL-6 correlate with prostate tumor burden and patient morbidity. The prostate tissue itself appears to be a source of IL-6 and its receptor. Furthermore, experimental data suggest that IL-6 is an autocrine and paracrine growth factor for androgen-independent prostate cancer cell lines. For example, inhibition of IL-6, with anti-IL-6 antibody, sensitizes androgen-independent prostate cancer cells to chemotherapeutic agents in vitro. Finally, IL-6 activates a variety of signal transduction cascades, some which stimulate androgen receptor activity, in prostate cancer cells. These data suggest that targeting IL-6 may have multiple benefits in prostate cancer patients.

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PubMed ID:: 11312117

DOI:: 10.1016/S1359-6101(00)00021-6

ScienceOpen disciplines: Chemistry

Keywords: Animals,Humans,Interleukin-6,analysis,metabolism,pharmacology,Male,Prostatic Neoplasms,drug therapy,physiopathology,Receptors, Androgen,Receptors, Interleukin-6,Signal Transduction,Tumor Cells, Cultured

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ScienceOpen disciplines: Chemistry

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