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One sequence, two ribozymes: implications for the emergence of new ribozyme folds.

Publication date: 2000-07-21

Keywords: Base Sequence, Catalysis, Evolution, Molecular, Gene Duplication, Hepatitis Delta Virus, enzymology, genetics, Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Point Mutation, RNA, metabolism, RNA, Catalytic, chemistry

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Abstract

We describe a single RNA sequence that can assume either of two ribozyme folds and catalyze the two respective reactions. The two ribozyme folds share no evolutionary history and are completely different, with no base pairs (and probably no hydrogen bonds) in common. Minor variants of this sequence are highly active for one or the other reaction, and can be accessed from prototype ribozymes through a series of neutral mutations. Thus, in the course of evolution, new RNA folds could arise from preexisting folds, without the need to carry inactive intermediate sequences. This raises the possibility that biological RNAs having no structural or functional similarity might share a common ancestry. Furthermore, functional and structural divergence might, in some cases, precede rather than follow gene duplication.

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PubMed ID:: 10903205

DOI:: 10.1126/science.289.5478.448

ScienceOpen disciplines: Chemistry

Keywords: Base Sequence,Catalysis,Evolution, Molecular,Gene Duplication,Hepatitis Delta Virus,enzymology,genetics,Molecular Sequence Data,Mutation,Nucleic Acid Conformation,Point Mutation,RNA,metabolism,RNA, Catalytic,chemistry

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ScienceOpen disciplines: Chemistry

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