Antidepressant effects of ketamine in depressed patients.

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Abstract

A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology of major depression and the mechanism of action of antidepressants. This is the first placebo-controlled, double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-aspartate (NMDA) receptor antagonist in patients with depression.

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Journal

Journal ID (iso-abbrev): Biol Psychiatry

Title: Biological psychiatry

Publisher: Elsevier BV

ISSN: 0006-3223

ISSN (Print): 0006-3223

Publication date (Electronic): Feb 15 2000

Volume: 47

Issue: 4

Affiliations

[1 ] Abraham Ribicoff Center Clinical Neuroscience Research Unit of the Connecticut Mental Health Center, New Haven 06519, USA.

Article

Publisher Item ID: S0006-3223(99)00230-9

DOI: 10.1016/s0006-3223(99)00230-9

PubMed ID: 10686270

SO-VID: 5d4564cc-1958-4e5a-b65d-49e6a1bcec4d

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