Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study.

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Abstract

Susceptibility to disease after infection by Mycobacterium tuberculosis is influenced by environmental and host genetic factors. Vitamin D metabolism leads to activation of macrophages and restricts the intracellular growth of M. tuberculosis. This effect may be influenced by polymorphisms at three sites in the vitamin D receptor (VDR) gene. We investigated the interaction between serum vitamin D (25-hydroxycholecalciferol) concentrations and VDR genotype on susceptibility to tuberculosis.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN: 0140-6736

ISSN (Print): 0140-6736

Publication date (Electronic): Feb 19 2000

Volume: 355

Issue: 9204

Affiliations

[1 ] Division of Infectious Diseases, Case Western Reserve University, Cleveland, OH, USA.

Article

Publisher Item ID: S0140-6736(99)02301-6

DOI: 10.1016/S0140-6736(99)02301-6

PubMed ID: 10696983

SO-VID: 5c457b4d-9f62-4b0a-bf0a-c7f7e2dde596

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